Product Name
Semaphorin-3E (SEMA3E), Recombinant Protein
Full Product Name
Recombinant Chicken Semaphorin-3E (SEMA3E), partial
Product Gene Name
SEMA3E recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
33-523. Partial, including the Sema Domain
Sequence
RQPRLRLSHK ELWDLNRTSV FHSPFGYLGL HIMLLDEYQE RLFVGGRDLL YSLSLDRISN NYREIHWPST PLQAEECIIK GRDADECANY VRVLHRYNRT HLLACGTGAF DPVCTFIRVG HPSEDHLFQL ESHKFERGRG RCPFDPTSSF TSILIGGELF TGLYSDYWGR DAAVFRTMNR MAHLRTEPDS EHLLKEPKFV GSYMIPDNED HDDNKVYLFF TEKALEAETS THAIYTRVGR VCVNDMGGQR IVVNKWSTFL KTRLVCSVPG RNGIDTHFDE LEDVFLLQTR DNKNPVIFGL FSTTSNIFRG YAICVYHMAI VRAAFNGPYA HKEGPEYYWA LYEGKVPYPR PGSCASKVNG GLYTTTKDYP DEAVHFARSH PLMYQPIKPV HKRPILVKTD GKYNLKQIAV DRVEAEDGQY DVLFIGTDNG IVLKVITIYN QETESMEEVI LEELQVFKVP IPILSMEISS KRQQLYIGTE SVIAQVKFHQ C
3D Structure
ModBase 3D Structure for O42237
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of SEMA3E recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for SEMA3E. It may not necessarily be applicable to this product.
NCBI Accession #
NP_989573.1
[Other Products]
NCBI GenBank Nucleotide #
NM_204242.1
[Other Products]
UniProt Primary Accession #
O42237
[Other Products]
UniProt Secondary Accession #
Q90666[Other Products]
UniProt Related Accession #
O42237[Other Products]
Molecular Weight
90,979 Da
NCBI Official Full Name
semaphorin-3E
NCBI Official Synonym Full Names
semaphorin 3E
NCBI Official Symbol
SEMA3E [Similar Products]
NCBI Official Synonym Symbols
semaphorin-3E
[Similar Products]
NCBI Protein Information
semaphorin-3E
UniProt Protein Name
Semaphorin-3E
UniProt Synonym Protein Names
Collapsin-5; COLL-5
Protein Family
Semaphorin
UniProt Gene Name
SEMA3E [Similar Products]
UniProt Synonym Gene Names
COLL5; COLL-5 [Similar Products]
UniProt Comments for SEMA3E
Plays an important role in signaling via the cell surface receptor PLXND1. Mediates reorganization of the actin cytoskeleton, leading to the retraction of cell projections. Promotes focal adhesion disassembly and inhibits adhesion of endothelial cells to the extracellular matrix. Regulates angiogenesis. Can down-regulate sprouting angiogenesis. Required for normal vascular patterning during embryogenesis. Induces the collapse and paralysis of neuronal growth cones. Plays an important role in ensuring the specificity of synapse formation ().
Research Articles on SEMA3E
1. Results suggest a molecular mechanism whereby ingrowth of retinal axons into the tectum can be regulated by semaphorin 3E/BDNF modulation without disturbing tectal axon growth out of the tectum mediated by Sema3A.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
