Aldehyde Dehydrogenase, mitochondrial, 18-517aa, Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 10; NC_005109.3 (47300331..47320877, complement). Location: 10q22

E Coli

Highly Purified
90% (SDS-PAGE)

Supplied as a liquid in 20 mM Tris-HCl buffer, pH 7.5, 1mM DTT, 1 mM EDTA, 10% glycerol.

For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Small volumes of Aldh3a2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

ALDH2 (Aldehyde dehydrogenase 2 family) belongs to the aldehyde dehydrogenase family which catalyze the chemical transformation from acetaldehyde to acetic acid and is the second enzyme of the major oxidative pathway of alcohol metabolism. There are two major liver isoforms of this enzyme, cytosolic and mitochondrial, and they can be also distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Recombinant

Molecular Biology; MB-Enzymes, Dehydrogenase

54.5kD[Similar Products]

aldehyde dehydrogenase 3 family, member A2

fatty aldehyde dehydrogenase; msALDH; aldehyde dehydrogenase 4; aldehyde dehydrogenase 3A2; microsomal aldehyde dehydrogenase; aldehyde dehydrogenase family 3 member A2; alcohol dehydrogenase family 3, subfamily A2; aldehyde dehydrogenase family 3, subfamily A2

Fatty aldehyde dehydrogenase

Aldh4; msALDH  [Similar Products]

AL3A2_RAT

ALDH3A2: Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid. Defects in ALDH3A2 are the cause of Sjoegren-Larsson syndrome (SLS). SLS is an autosomal recessive neurocutaneous disorder characterized by a combination of severe mental retardation, spastic di- or tetraplegia and congenital ichthyosis (increased keratinization). Ichthyosis is usually evident at birth, neurologic symptoms appear in the first or second year of life. Most patients have an IQ of less than 60. Additional clinical features include glistening white spots on the retina, seizures, short stature and speech defects. Belongs to the aldehyde dehydrogenase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Mitochondrial; Oxidoreductase; Membrane protein, integral; Endoplasmic reticulum; Lipid Metabolism - glycerolipid; Carbohydrate Metabolism - ascorbate and aldarate; Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - arginine and proline; Lipid Metabolism - fatty acid; Carbohydrate Metabolism - pyruvate; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 1.2.1.3; Amino Acid Metabolism - histidine; Other Amino Acids Metabolism - beta-alanine; Carbohydrate Metabolism - propanoate; Amino Acid Metabolism - lysine degradation; Secondary Metabolites Metabolism - limonene and pinene degradation; Amino Acid Metabolism - valine, leucine and isoleucine degradation

Cellular Component: mitochondrion; intracellular membrane-bound organelle; endoplasmic reticulum; mitochondrial inner membrane; integral to membrane; peroxisome; nucleus; cytosol

Molecular Function: long-chain-alcohol oxidase activity; aldehyde dehydrogenase (NAD) activity; aldehyde dehydrogenase [NAD(P)+] activity; 3-chloroallyl aldehyde dehydrogenase activity; long-chain-aldehyde dehydrogenase activity

Biological Process: phytol metabolic process; response to reactive oxygen species; epidermis development; central nervous system development; formaldehyde metabolic process; aldehyde metabolic process; sesquiterpenoid metabolic process; peripheral nervous system development

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