Product Name
Patatin-like phospholipase domain-containing protein 3 (PNPLA3), Polyclonal Antibody
Popular Item
Full Product Name
Rabbit anti-human Patatin-like phospholipase domain-containing protein 3 polyclonal Antibody(PNPLA3)
Product Synonym Names
Acylglycerol O-acyltransferase; Adiponutrin; Calcium-independent phospholipase A2-epsilon; iPLA2-epsilon; PNPLA3; ADPN; C22orf20
Product Gene Name
anti-PNPLA3 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9NST1
Purity/Purification
Antigen Affinity Purified
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Immunogen
Recombinant human Patatin-like phospholipase domain-containing protein 3 protein (377-481aa)
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-49594 / sc-130944 / sc-134755
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-PNPLA3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-PNPLA3 antibody
Multifunctional enzyme which has both triacylglycerol lipase and acylglycerol O-acyltransferase activities.
Applications Tested/Suitable for anti-PNPLA3 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-PNPLA3 antibody
Recommended dilution: WB:1:200-1000
IHC:1:20-1:200
Western Blot (WB) of anti-PNPLA3 antibody
All lanes: Patatin-like phospholipase domain-containing protein 3 antibody at 8ug/ml+HepG2 whole cell lysate
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 53kDa
Observed band size: 53kDa
Immunohistochemistry (IHC) of anti-PNPLA3 antibody
Immunohistochemistry of paraffin-embedded human skin using MBS1499072 at dilution 1:100
NCBI/Uniprot data below describe general gene information for PNPLA3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_079501.2
[Other Products]
NCBI GenBank Nucleotide #
NM_025225.2
[Other Products]
UniProt Primary Accession #
Q9NST1
[Other Products]
UniProt Secondary Accession #
Q6P1A1; Q96CB4; B0QYI0; B2RCL3; B3KW00[Other Products]
UniProt Related Accession #
Q9NST1[Other Products]
Molecular Weight
52,485 Da
NCBI Official Full Name
patatin-like phospholipase domain-containing protein 3
NCBI Official Synonym Full Names
patatin like phospholipase domain containing 3
NCBI Official Symbol
PNPLA3 [Similar Products]
NCBI Official Synonym Symbols
ADPN; C22orf20; iPLA(2)epsilon
[Similar Products]
NCBI Protein Information
patatin-like phospholipase domain-containing protein 3
UniProt Protein Name
Patatin-like phospholipase domain-containing protein 3
UniProt Synonym Protein Names
Acylglycerol O-acyltransferase (EC:2.3.1.-); Adiponutrin; Calcium-independent phospholipase A2-epsilon; iPLA2-epsilon
Protein Family
Patatin-like phospholipase domain-containing protein
UniProt Gene Name
PNPLA3 [Similar Products]
UniProt Synonym Gene Names
ADPN; C22orf20; iPLA2-epsilon [Similar Products]
UniProt Entry Name
PLPL3_HUMAN
NCBI Summary for PNPLA3
The protein encoded by this gene is a triacylglycerol lipase that mediates triacylglycerol hydrolysis in adipocytes. The encoded protein, which appears to be membrane bound, may be involved in the balance of energy usage/storage in adipocytes. [provided by RefSeq, Jul 2008]
UniProt Comments for PNPLA3
PNPLA3: Multifunctional enzyme which has both triacylglycerol lipase and acylglycerol O-acyltransferase activities. Genetic variations in PNPLA3 are a cause of susceptibility to non-alcoholic fatty liver disease type 1 (NAFLD1). A condition characterized by an accumulation of excess triglyceride in the liver, a condition known as hepatic steatosis (or fatty liver), which is associated with adverse metabolic consequences, including insulin resistance and dyslipidemia. In a subset of individuals, hepatic steatosis promotes an inflammatory response in the liver, referred to as steatohepatitis, which can progress to cirrhosis and liver cancer. NAFLD is the most common form of liver disease in Western countries. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Secondary Metabolites Metabolism - limonene and pinene degradation; Amino Acid Metabolism - phenylalanine; Lipid Metabolism - glycerolipid; Amino Acid Metabolism - tyrosine; EC 3.1.1.3; Phospholipase; Transferase; Lipid Metabolism - glycerophospholipid
Chromosomal Location of Human Ortholog: 22q13.31
Cellular Component: endoplasmic reticulum membrane; integral to membrane; membrane
Molecular Function: diolein transacylation activity; mono-olein transacylation activity; phospholipase A2 activity; triacylglycerol lipase activity
Biological Process: glycerophospholipid biosynthetic process; phospholipid metabolic process; triacylglycerol biosynthetic process; triacylglycerol catabolic process
Research Articles on PNPLA3
1. findings suggest that the rs738409 polymorphism in PNPLA3 gene confers high cross-ethnicity risk for NAFLD and NASH development
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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