DUX4, Polyclonal Antibody

Double homeobox 4; Double homeobox protein 10; Double homeobox protein 4; Double homeobox protein 4/10; DUX10; DUX4L; DUX4L1

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

DUX4 antibody detects endogenous levels of total DUX4

The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.

Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

1mg/ml (lot specific)

Store at -20 degree C. Stable for 12 months from date of receipt.

Manufactured in an ISO 9001:2015 Certified Laboratory.

Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.

Small volumes of anti-DUX4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Function: Involved in transcriptional regulation. May regulate microRNA (miRNA) expression.
Subunit Structure: May exist as a monomer or a dimer.
Similarity: Both homeobox domains confer nuclear targeting. Belongs to the paired homeobox family.

Western Blot (WB), ELISA (EIA)

WB: 1:1000-3000

Western blot analysis of DUX4 using Jurkat whole cell lysates

Observed: 45 kDa
Predicted: 45 kDa

double homeobox 4

double homeobox protein 4

Double homeobox protein 4

DUX10  [Similar Products]

This gene is located within a D4Z4 repeat array in the subtelomeric region of chromosome 4q. The D4Z4 repeat is polymorphic in length; a similar D4Z4 repeat array has been identified on chromosome 10. Each D4Z4 repeat unit has an open reading frame (named DUX4) that encodes two homeoboxes; the repeat-array and ORF is conserved in other mammals. The encoded protein has been reported to function as a transcriptional activator of paired-like homeodomain transcription factor 1 (PITX1; GeneID 5307). Contraction of the macrosatellite repeat causes autosomal dominant facioscapulohumeral muscular dystrophy (FSHD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

Involved in transcriptional regulation. May regulate microRNA (miRNA) expression.

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