Full Product Name
DUX4 Antibody
Product Gene Name
anti-DUX4 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9UBX2
Other Notes
Small volumes of anti-DUX4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Western Blot (WB) of anti-DUX4 antibody
Western blot analysis DUX4 using Jurkat whole cell lysates
NCBI/Uniprot data below describe general gene information for DUX4. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001280727.1
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NCBI GenBank Nucleotide #
NM_001293798.2
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UniProt Primary Accession #
Q9UBX2
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UniProt Related Accession #
Q9UBX2[Other Products]
Molecular Weight
44,940 Da
NCBI Official Full Name
double homeobox protein 4
NCBI Official Synonym Full Names
double homeobox 4
NCBI Official Symbol
DUX4 [Similar Products]
NCBI Official Synonym Symbols
DUX4L
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NCBI Protein Information
double homeobox protein 4
UniProt Protein Name
Double homeobox protein 4
UniProt Synonym Protein Names
Double homeobox protein 10
Protein Family
Double homeobox protein
UniProt Gene Name
DUX4 [Similar Products]
NCBI Summary for DUX4
This gene is located within a D4Z4 repeat array in the subtelomeric region of chromosome 4q. The D4Z4 repeat is polymorphic in length; a similar D4Z4 repeat array has been identified on chromosome 10. Each D4Z4 repeat unit has an open reading frame (named DUX4) that encodes two homeoboxes; the repeat-array and ORF is conserved in other mammals. The encoded protein has been reported to function as a transcriptional activator of paired-like homeodomain transcription factor 1 (PITX1; GeneID 5307). Contraction of the macrosatellite repeat causes autosomal dominant facioscapulohumeral muscular dystrophy (FSHD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
UniProt Comments for DUX4
Involved in transcriptional regulation. May regulate microRNA (miRNA) expression.
Research Articles on DUX4
1. We discuss the involvement of this rearrangement in Facioscapulohumeral dystrophy (FSHD), since all mutations in SMCHD1 are not associated with D4Z4 hypomethylation and do not always segregate with the disease
Precautions
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Disclaimer
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