Full Product Name
DUX4 Antibody - middle region
Product Gene Name
anti-DUX4 antibody
[Similar Products]
Product Synonym Gene Name
DUX4L[Similar Products]
Antibody/Peptide Pairs
DUX4 peptide (MBS3235166) is used for blocking the activity of DUX4 antibody (MBS3210210)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
Synthetic peptide located within the following region: ESRPWPGRRG PPEGRRKRTA VTGSQTALLL RAFEKDRFPG IAAREELARE
3D Structure
ModBase 3D Structure for Q9UBX2
Purity/Purification
Affinity Purified
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human DUX4
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-DUX4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-DUX4 antibody
This is a rabbit polyclonal antibody against DUX4. It was validated on Western Blot
Target Description: This gene is located within a D4Z4 repeat array in the subtelomeric region of chromosome 4q. The D4Z4 repeat is polymorphic in length; a similar D4Z4 repeat array has been identified on chromosome 10. Each D4Z4 repeat unit has an open reading frame (named DUX4) that encodes two homeoboxes; the repeat-array and ORF is conserved in other mammals. The encoded protein has been reported to function as a transcriptional activator of paired-like homeodomain transcription factor 1 (PITX1; GeneID 5307). Contraction of the macrosatellite repeat causes autosomal dominant facioscapulohumeral muscular dystrophy (FSHD). Alternative splicing results in multiple transcript variants.
Product Categories/Family for anti-DUX4 antibody
Polyclonal; Transcription Factor;
Applications Tested/Suitable for anti-DUX4 antibody
Western Blot (WB)
Western Blot (WB) of anti-DUX4 antibody
Host: Rabbit
Target Name: DUX4
Sample Type: THP-1 Whole cell lysates
Antibody Dilution: 1.0ug/ml
NCBI/Uniprot data below describe general gene information for DUX4. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001280727.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001293798.1
[Other Products]
UniProt Primary Accession #
Q9UBX2
[Other Products]
UniProt Related Accession #
Q9UBX2[Other Products]
NCBI Official Full Name
double homeobox protein 4 isoform DUX4-fl
NCBI Official Synonym Full Names
double homeobox 4
NCBI Official Symbol
DUX4 [Similar Products]
NCBI Official Synonym Symbols
DUX4L
[Similar Products]
NCBI Protein Information
double homeobox protein 4
UniProt Protein Name
Double homeobox protein 4
UniProt Synonym Protein Names
Double homeobox protein 10
Protein Family
Double homeobox protein
UniProt Gene Name
DUX4 [Similar Products]
UniProt Entry Name
DUX4_HUMAN
NCBI Summary for DUX4
This gene is located within a D4Z4 repeat array in the subtelomeric region of chromosome 4q. The D4Z4 repeat is polymorphic in length; a similar D4Z4 repeat array has been identified on chromosome 10. Each D4Z4 repeat unit has an open reading frame (named DUX4) that encodes two homeoboxes; the repeat-array and ORF is conserved in other mammals. The encoded protein has been reported to function as a transcriptional activator of paired-like homeodomain transcription factor 1 (PITX1; GeneID 5307). Contraction of the macrosatellite repeat causes autosomal dominant facioscapulohumeral muscular dystrophy (FSHD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
UniProt Comments for DUX4
DUX4: May be involved in transcriptional regulation. Defects in DUX4 may be the cause of facioscapulohumeral muscular dystrophy (FSHD). FSHD is characterized by weakness of the muscles of the face, upper-arm and shoulder girdle. Severity is highly variable. Weakness is slowly progressive and about 20% of affected individuals eventually require a wheelchair. Approximately 70-90% of individuals have inherited the disease-causing deletion from a parent, and approximately 10-30% of affected individuals have FSHD as the result of a de novo deletion. Offsprings of an affected individual have a 50% chance of inheriting the deletion. Belongs to the paired homeobox family.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 4q35
Research Articles on DUX4
1. Cyclic AMP production reduces DUX4 expression through a protein kinase A-dependent mode of action in facioscapulohumeral muscular dystrophy patient myotubes.
Precautions
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Disclaimer
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