Lubricin / PRG4, Blocking Peptide

PRG4; proteoglycan 4; CACP; FLJ32635; HAPO; JCAP; MSF; SZP; bG174L6.2; Jacobs camptodactyly-arthropathy-pericarditis syndrome; articular superficial zone protein; bG174L6.2 (MSF: megakaryocyte stimulating factor); camptodactyly, arthropathy, coxa vara,; Lubricin; Lubricin / PRG4

For Research Use Only. Not for use in diagnostic procedures.

100ug of dried peptide

Shipped at ambient temperature, store at -20 degree C

Manufactured in an ISO 9001:2008 Certified Laboratory.

Small volumes of PRG4 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

proteoglycan 4

proteoglycan 4

Proteoglycan 4

MSF; SZP  [Similar Products]

PRG4_HUMAN

The protein encoded by this gene is a large proteoglycan that is synthesized by chondrocytes located at the surface of articular cartilage and by some synovial lining cells. This protein contains both chondroitin sulfate and keratan sulfate glycosaminoglycans. It functions as a boundary lubricant at the cartilage surface and contributes to the elastic absorption and energy dissipation of synovial fluid. Mutations in this gene result in camptodactyly-arthropathy-coxa vara-pericarditis syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

PRG4: Plays a role in boundary lubrication within articulating joints. Prevents protein deposition onto cartilage from synovial fluid by controlling adhesion-dependent synovial growth and inhibiting the adhesion of synovial cells to the cartilage surface. Defects in PRG4 are the cause of camptodactyly- arthropathy-coxa vara-pericarditis syndrome (CACP); also known as Jacobs syndrome. CACP is an autosomal recessive disorder. Individuals with CACP have normal appearing joints at birth but with advancing age develop joint failure associated with noninflammatory synoviocyte hyperplasia and subintimal fibrosis of the synovial capsule. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1q25-q31

Cellular Component: extracellular region

Molecular Function: polysaccharide binding; scavenger receptor activity

Biological Process: cell proliferation; immune response; receptor-mediated endocytosis

Disease: Camptodactyly-arthropathy-coxa Vara-pericarditis Syndrome

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