Full Product Name
PRG4 Antibody - N-terminal region
Product Gene Name
anti-PRG4 antibody
[Similar Products]
Product Synonym Gene Name
MSF; SZP; CACP; HAPO; JCAP[Similar Products]
Antibody/Peptide Pairs
PRG4 peptide (MBS3246341) is used for blocking the activity of PRG4 antibody (MBS3221608)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
Synthetic peptide located within the following region: SKNSAANREL QKKLKVKDNK KNRTKKKPTP KPPVVDEAGS GLDNGDFKVT
3D Structure
ModBase 3D Structure for Q92954
Purity/Purification
Affinity purified
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human PRG4
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-PRG4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-PRG4 antibody
The protein encoded by this gene is a large proteoglycan that is synthesized by chondrocytes located at the surface of articular cartilage and by some synovial lining cells. This protein contains both chondroitin sulfate and keratan sulfate glycosaminoglycans. It functions as a boundary lubricant at the cartilage surface and contributes to the elastic absorption and energy dissipation of synovial fluid. Mutations in this gene result in camptodactyly-arthropathy-coxa vara-pericarditis syndrome. Alternative splicing results in multiple transcript variants.
Product Categories/Family for anti-PRG4 antibody
Polyclonal; Disease Related;
Applications Tested/Suitable for anti-PRG4 antibody
Western Blot (WB)
Western Blot (WB) of anti-PRG4 antibody
Host: Rabbit
Target Name: PRG4
Sample Tissue: Human A172 Whole Cell lysates
Antibody Dilution: 1ug/ml
NCBI/Uniprot data below describe general gene information for PRG4. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001121180.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001127708.2
[Other Products]
UniProt Primary Accession #
Q92954
[Other Products]
UniProt Related Accession #
Q92954[Other Products]
NCBI Official Full Name
proteoglycan 4 isoform B
NCBI Official Synonym Full Names
proteoglycan 4
NCBI Official Symbol
PRG4 [Similar Products]
NCBI Official Synonym Symbols
MSF; SZP; CACP; HAPO; JCAP
[Similar Products]
NCBI Protein Information
proteoglycan 4
UniProt Protein Name
Proteoglycan 4
UniProt Synonym Protein Names
Lubricin; Megakaryocyte-stimulating factor; Superficial zone proteoglycan
Protein Family
Proteoglycan
UniProt Gene Name
PRG4 [Similar Products]
UniProt Synonym Gene Names
MSF; SZP [Similar Products]
NCBI Summary for PRG4
The protein encoded by this gene is a large proteoglycan that is synthesized by chondrocytes located at the surface of articular cartilage and by some synovial lining cells. This protein contains both chondroitin sulfate and keratan sulfate glycosaminoglycans. It functions as a boundary lubricant at the cartilage surface and contributes to the elastic absorption and energy dissipation of synovial fluid. Mutations in this gene result in camptodactyly-arthropathy-coxa vara-pericarditis syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
UniProt Comments for PRG4
PRG4: Plays a role in boundary lubrication within articulating joints. Prevents protein deposition onto cartilage from synovial fluid by controlling adhesion-dependent synovial growth and inhibiting the adhesion of synovial cells to the cartilage surface. Defects in PRG4 are the cause of camptodactyly- arthropathy-coxa vara-pericarditis syndrome (CACP); also known as Jacobs syndrome. CACP is an autosomal recessive disorder. Individuals with CACP have normal appearing joints at birth but with advancing age develop joint failure associated with noninflammatory synoviocyte hyperplasia and subintimal fibrosis of the synovial capsule. 6 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 1q31.1
Cellular Component: extracellular matrix
Molecular Function: polysaccharide binding; scavenger receptor activity
Biological Process: cell proliferation; immune response; receptor-mediated endocytosis
Disease: Camptodactyly-arthropathy-coxa Vara-pericarditis Syndrome
Research Articles on PRG4
1. Inflammatory Biomarker Profiling in Total Joint Arthroplasty and Its Relevance to Circulating Levels of Lubricin, a Novel Proteoglycan.
Precautions
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Disclaimer
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