Product Name
Kappa-type opioid receptor (Oprk1), Recombinant Protein
Full Product Name
Recombinant Mouse Kappa-type opioid receptor (Oprk1)
Product Synonym Names
Recombinant Kappa-type opioid receptor (Oprk1); Kappa-type opioid receptor; K-OR-1; KOR-1; MSL-1
Product Gene Name
Oprk1 recombinant protein
[Similar Products]
Product Synonym Gene Name
Oprk1[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
MESPIQIFRG DPGPTCSPSA CLLPNSSSWF PNWAESDSNG SVGSEDQQLE SAHISPAIPV IITAVYSVVF VVGLVGNSLV MFVIIRYTKM KTATNIYIFN LALADALVTT TMPFQSAVYL MNSWPFGDVL CKIVISIDYY NMFTSIFTLT MMSVDRYIAV CHPVKALDFR TPLKAKIINI CIWLLASSVG ISAIVLGGTK VREDVDVIEC SLQFPDDEYS WWDLFMKICV FVFAFVIPVL IIIVCYTLMI LRLKSVRLLS GSREKDRNLR RITKLVLVVV AVFIICWTPI HIFILVEALG STSHSTAALS SYYFCIALGY TNSSLNPVLY AFLDENFKRC FRDFCFPIKM RMERQSTNRV RNTVQDPASM RDVGGMNKPV
Chromosome Location
Chromosome: 1; NC_000067.6 (5588493..5606133). Location: 1 A2-A3; 1 1.89 cM
3D Structure
ModBase 3D Structure for P33534
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>=90% (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Mus musculus (Mouse)
Preparation and Storage
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Oprk1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for Oprk1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001191300.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001204371.1
[Other Products]
UniProt Primary Accession #
P33534
[Other Products]
UniProt Related Accession #
P33534[Other Products]
Molecular Weight
42,652 Da[Similar Products]
NCBI Official Full Name
kappa-type opioid receptor
NCBI Official Synonym Full Names
opioid receptor, kappa 1
NCBI Official Symbol
Oprk1 [Similar Products]
NCBI Official Synonym Symbols
KOR; R21; KOR-1; MSL-1; Oprk2; K-OR-1
[Similar Products]
NCBI Protein Information
kappa-type opioid receptor; opioid receptor, kappa 2
UniProt Protein Name
Kappa-type opioid receptor
UniProt Synonym Protein Names
MSL-1
Protein Family
Kappa-type opioid receptor
UniProt Gene Name
Oprk1 [Similar Products]
UniProt Synonym Gene Names
K-OR-1; KOR-1 [Similar Products]
UniProt Entry Name
OPRK_MOUSE
UniProt Comments for Oprk1
KOR-1: kappa-type opioid receptor. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Receptor for dynorphins. May play a role in arousal and regulation of autonomic and neuroendocrine functions.
Protein type: Membrane protein, integral; GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR
Cellular Component: neuron projection; membrane; integral to plasma membrane; plasma membrane; integral to membrane
Molecular Function: G-protein coupled receptor activity; neuropeptide binding; signal transducer activity; opioid receptor activity
Biological Process: synaptic transmission; G-protein signaling, coupled to cyclic nucleotide second messenger; G-protein coupled receptor protein signaling pathway; neuropeptide signaling pathway; behavior; opioid receptor, adenylate cyclase inhibiting pathway; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); locomotory behavior; immune response; regulation of saliva secretion; signal transduction; sensory perception of pain; defense response to virus
Research Articles on Oprk1
1. these data suggest that endogenous prodynorphin-derived peptides sufficiently activate KOP receptors during acute seizures, and importantly in situations of reduced dynorphinergic signaling-like in epilepsy-the exogenous activation of KOP receptors might also have strong neuroprotective effects during excitotoxic events.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
