Product Name
ATP-sensitive inward rectifier potassium channel 11 (KCNJ11), Recombinant Protein
Full Product Name
Recombinant Rabbit ATP-sensitive inward rectifier potassium channel 11 (KCNJ11)
Product Synonym Names
Recombinant ATP-sensitive inward rectifier potassium channel 11 (KCNJ11); ATP-sensitive inward rectifier potassium channel 11; Inward rectifier K(+) channel Kir6.2 Potassium channel, inwardly rectifying subfamily J member 11
Product Gene Name
KCNJ11 recombinant protein
[Similar Products]
Product Synonym Gene Name
KCNJ11; KIR62[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
MLSRKGIIPE EYVLTRLAED PAEPRYRARE RRARFVSKKG NCNVAHKNIR EQGRFLQDVF TTLVDLKWTH TLLIFTMSFL CSWLLFAMVW WLIAFAHGDL APGEGAAVPC VTSIHSFSSA FLFSIEVQVT IGFGGRMVTE ECPLAILILI VQNIVGLMIN AIMLGCIFMK TAQAHRRAET LIFSKHAVIA LRQGRLCFML RVGDLRKSMI ISATIHMQVV RKTTSPEGEV VPLHQVDIPM ENGVGGNSIF LVAPLIIHHV IDANSPLYDL APSDLHHHQD LEIIVILEGV VETTGITTQA RTSYLADEIL WGQRFVPIVA EEDGRYSVDY SKFGNTVKVP TPLCTARQLD EDRSLLDALT LTSARGPLRK RSVPVAKAKP KFSISPDSLS
Chromosome Location
chromosome: Un
3D Structure
ModBase 3D Structure for O02822
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>=90% (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Oryctolagus cuniculus (Rabbit)
Preparation and Storage
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of KCNJ11 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for KCNJ11. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001075486.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001082017.1
[Other Products]
UniProt Primary Accession #
O02822
[Other Products]
UniProt Related Accession #
O02822[Other Products]
Molecular Weight
43,438 Da[Similar Products]
NCBI Official Full Name
ATP-sensitive inward rectifier potassium channel 11
NCBI Official Symbol
KCNJ11 [Similar Products]
NCBI Official Synonym Symbols
KIR6.2
[Similar Products]
NCBI Protein Information
ATP-sensitive inward rectifier potassium channel 11; inward rectifier K(+) channel Kir6.2; inwardly rectifying potassium channel Kir6.2; ATP-sensitive inward rectifier potassium channel Kir6.2; potassium channel, inwardly rectifying subfamily J member 11
UniProt Protein Name
ATP-sensitive inward rectifier potassium channel 11
UniProt Synonym Protein Names
Inward rectifier K(+) channel Kir6.2; Potassium channel, inwardly rectifying subfamily J member 11
Protein Family
ATP-sensitive inward rectifier potassium channel
UniProt Gene Name
KCNJ11 [Similar Products]
UniProt Synonym Gene Names
KIR62 [Similar Products]
UniProt Entry Name
IRK11_RABIT
UniProt Comments for KCNJ11
Function: This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium. Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation
By similarity.
Subunit structure: Interacts with ABCC8/SUR. Interacts with ABCC9/SUR2
By similarity.
Subcellular location: Membrane; Multi-pass membrane protein.
Sequence similarities: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ11 subfamily. [View classification]
Research Articles on KCNJ11
1. Although the expression level of Kir6.2 channel subtype does not differ between aortic smooth muscle cells of control and hypertrophied models, those of Kir6.1 and SUR2B subtypes are reduced in left ventricular hypertrophy models.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
