Product Name
IL-31 (Il31), Polyclonal Antibody
Popular Item
Full Product Name
IL-31 Antibody
Product Synonym Names
IL-31; 1700013B14Rik; Interleukin-31; IL-31; interleukin 31
Product Gene Name
anti-Il31 antibody
[Similar Products]
Antibody/Peptide Pairs
IL-31 peptide (MBS152788) is used for blocking the activity of IL-31 antibody (MBS151553)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q6EAL8
Purity/Purification
IL-31 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Immunogen
IL-31 antibody was raised against a 16 amino acid synthetic peptide from near the amino terminus of mouse IL-31.
The immunogen is located within amino acids 30 - 80 of IL-31.
Buffer
IL-31 Antibody is supplied in PBS containing 0.02% sodium azide.
Preparation and Storage
IL-31 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Other Notes
Small volumes of anti-Il31 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-Il31 antibody
IL-31 Antibody: Interleukin-31 (IL-31) is a recently discovered T-cell cytokine closely related to IL-6 type cytokines and is preferentially produced by T helper type 2 cells. IL-31 activity is mediated through the ligand-induced oligomerization of a dimeric receptor complex containing IL-31 receptor A and oncostatin M receptor. In response to IL-31 binding, these proteins activate the JAK/STAT and the AKT signaling pathways. RNA levels of IL-31 receptor A and oncostatin M receptor are induced in activated monocytes but are expressed constitutively in epithelial cells. IL-31, when overexpressed in transgenic mice, results in the development of pruritis, alopecia, and skin lesions and in humans may result in atopic dermatitis, suggesting that IL-31 may represent a novel target for antipruritic drug development.
Applications Tested/Suitable for anti-Il31 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry-paraffin (IHC-P)
Application Notes for anti-Il31 antibody
IL-31 antibody can be used for the detection of IL-31 by Western blot at 2.5 - 10 mug/mL. Antibody can also be used for immunohistochemistry starting at 10 mug/mL.
Western Blot (WB) of anti-Il31 antibody
Western blot analysis of IL-31 in RAW264.7 cell lysate with IL-31 antibody at (A) 2.5, (B) 5 and (C) 10 μg/mL.
Immunohistochemistry (IHC) of anti-Il31 antibody
Immunohistochemistry of IL-31 in rat skeletal muscle tissue with IL-31 antibody at 10 μg/mL.
NCBI/Uniprot data below describe general gene information for Il31. It may not necessarily be applicable to this product.
NCBI Accession #
AAS82846
[Other Products]
UniProt Primary Accession #
Q6EAL8
[Other Products]
UniProt Related Accession #
Q6EAL8[Other Products]
Molecular Weight
18,120 Da
NCBI Official Full Name
interleukin 31
NCBI Official Synonym Full Names
interleukin 31
NCBI Official Symbol
Il31 [Similar Products]
NCBI Official Synonym Symbols
1700013B14Rik
[Similar Products]
NCBI Protein Information
interleukin-31; IL-31
UniProt Protein Name
Interleukin-31
Protein Family
Interleukin
UniProt Gene Name
Il31 [Similar Products]
UniProt Synonym Gene Names
IL-31 [Similar Products]
UniProt Entry Name
IL31_MOUSE
UniProt Comments for Il31
IL31: Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR. IL31 may function in skin immunity
Protein type: Secreted; Secreted, signal peptide; Cytokine
Cellular Component: extracellular space; extracellular region
Molecular Function: cytokine activity
Biological Process: immune system process
Research Articles on Il31
1. Data not only illustrate various functions that cysteines perform during IL-31 biosynthesis and secretion, but also highlight their potential roles in cytokine effector functions.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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