Product Name
Cadherin-3 (CDH3), Polyclonal Antibody
Full Product Name
Rabbit anti-human Cadherin-3 polyclonal Antibody(CDH3), Biotin conjugated
Product Synonym Names
Placental cadherin; P-cadherin; CDH3; CDHP
Product Gene Name
anti-CDH3 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P22223
Purity/Purification
Caprylic Acid Ammonium Sulfate Precipitation Purified
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Immunogen
Recombinant human Cadherin-3 protein(117-360aa)
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-31027 / sc-31026 / sc-1501 / sc-7893 / sc-10733
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-CDH3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CDH3 antibody
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
Applications Tested/Suitable for anti-CDH3 antibody
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for CDH3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001784.2
[Other Products]
NCBI GenBank Nucleotide #
NM_001793.5
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UniProt Primary Accession #
P22223
[Other Products]
UniProt Secondary Accession #
Q05DI6; B2R6F4[Other Products]
UniProt Related Accession #
P22223[Other Products]
Molecular Weight
86,552 Da
NCBI Official Full Name
cadherin-3 isoform 1 preproprotein
NCBI Official Synonym Full Names
cadherin 3
NCBI Official Symbol
CDH3 [Similar Products]
NCBI Official Synonym Symbols
CDHP; HJMD; PCAD
[Similar Products]
NCBI Protein Information
cadherin-3
UniProt Protein Name
Cadherin-3
UniProt Synonym Protein Names
Placental cadherin; P-cadherin
UniProt Gene Name
CDH3 [Similar Products]
UniProt Synonym Gene Names
CDHP; P-cadherin [Similar Products]
UniProt Entry Name
CADH3_HUMAN
NCBI Summary for CDH3
This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a gene cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene are associated with hypotrichosis with juvenile macular dystrophy and ectodermal dysplasia, ectrodactyly, and macular dystrophy syndrome (EEMS). [provided by RefSeq, Nov 2015]
UniProt Comments for CDH3
CDH3: Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Interacts with CDCP1. Expressed in some normal epithelial tissues and in some carcinoma cell lines. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 16q22.1
Cellular Component: cell-cell adherens junction; cytoplasm; integral to membrane; plasma membrane
Molecular Function: calcium ion binding
Biological Process: cell adhesion; cell-cell adhesion; hair cycle process; homophilic cell adhesion; intercellular junction assembly and maintenance; keratinization; negative regulation of catagen; negative regulation of transforming growth factor-beta2 production; positive regulation of insulin-like growth factor receptor signaling pathway; positive regulation of melanin biosynthetic process; positive regulation of monophenol monooxygenase activity; response to drug; retinal homeostasis; visual perception; Wnt receptor signaling pathway through beta-catenin; wound healing
Disease: Ectodermal Dysplasia, Ectrodactyly, And Macular Dystrophy Syndrome; Hypotrichosis, Congenital, With Juvenile Macular Dystrophy
Research Articles on CDH3
1. The P-cadherin structure and packing arrangement provide new and valuable information towards the complete structural characterization of the cadherin dimerization pathway.
Precautions
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Disclaimer
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