Product Name
Cadherin-3 (Cdh3), Recombinant Protein
Full Product Name
Cadherin-3
Product Gene Name
Cdh3 recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
100-822aa; full length protein
Sequence
EWVMPPIFVP ENGKGPFPQR LNQLKSNKDR GTKIFYSITG PGADSPPEGV FTIEKESGWL LLHMPLDREK IVKYELYGHA VSENGASVEE PMNISIIVTD QNDNKPKFTQ DTFRGSVLEG VMPGTSVMQV TATDEDDAVN TYNGVVAYSI HSQEPKEPHD LMFTIHKSTG TISVISSGLD REKVPEYRLT VQATDMDGEG STTTAEAVVQ ILDANDNAPE FEPQKYEAWV PENEVGHEVQ RLTVTDLDVP NSPAWRATYH IVGGDDGDHF TITTHPETNQ GVLTTKKGLD FEAQDQHTLY VEVTNEAPFA VKLPTATATV VVHVKDVNEA PVFVPPSKVI EAQEGISIGE LVCIYTAQDP DKEDQKISYT ISRDPANWLA VDPDSGQITA AGILDREDEQ FVKNNVYEVM VLATDSGNPP TTGTGTLLLT LTDINDHGPI PEPRQIIICN QSPVPQVLNI TDKDLSPNSS PFQAQLTHDS DIYWMAEVSE KGDTVALSLK KFLKQDTYDL HLSLSDHGNR EQLTMIRATV CDCHGQVFND CPRPWKGGFI LPILGAVLAL LTLLLALLLL VRKKRKVKEP LLLPEDDTRD NVFYYGEEGG GEEDQDYDIT QLHRGLEARP EVVLRNDVVP TFIPTPMYRP RPANPDEIGN FIIENLKAAN TDPTAPPYDS LLVFDYEGSG SDAASLSSLT TSASDQDQDY NYLNEWGSRF KKLADMYGGG EDD
3D Structure
ModBase 3D Structure for P10287
Host
Cell Free Expression
Form/Format
Liquid containing glycerol
Species
Mus musculus (Mouse)
Storage Buffer
Tris-based buffer, 50% glycerol.
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Cdh3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
Cdh3 recombinant protein
This is a recombinant transmembrane protein expressed in a cell-free expression system.
Product Categories/Family for Cdh3 recombinant protein
Transmembrane Protein
NCBI/Uniprot data below describe general gene information for Cdh3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001032898.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001037809.5
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UniProt Primary Accession #
P10287
[Other Products]
UniProt Secondary Accession #
Q61465; Q8BSL6[Other Products]
UniProt Related Accession #
P10287[Other Products]
Molecular Weight
90,612 Da
NCBI Official Full Name
cadherin-3 isoform a preproprotein
NCBI Official Synonym Full Names
cadherin 3
NCBI Official Symbol
Cdh3 [Similar Products]
NCBI Official Synonym Symbols
Cadp; Cdhp; Pcad; AI385538; P-cadherin
[Similar Products]
NCBI Protein Information
cadherin-3
UniProt Protein Name
Cadherin-3
UniProt Synonym Protein Names
Placental cadherin; P-cadherin
UniProt Gene Name
Cdh3 [Similar Products]
UniProt Synonym Gene Names
Cdhp; P-cadherin [Similar Products]
UniProt Entry Name
CADH3_MOUSE
NCBI Summary for Cdh3
This gene encodes a calcium-dependent cell-cell adhesion protein containing five cadherin domains. The encoded protein plays a role in epithelial outgrowth, such as that which occurs during the development of hair follicles and limb buds. Loss of function of the related gene in humans results in ectodermal dysplasia, ectrodactyly, and macular dystrophy and congential hypotrichosis with juvenile macular dystrophy. This gene is located in the vicinity of similar cadherin genes on chromosome 8. The proprotein is further cleaved into a functional chain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]
UniProt Comments for Cdh3
CDH3: Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Interacts with CDCP1. Expressed in some normal epithelial tissues and in some carcinoma cell lines. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Cell adhesion
Cellular Component: cell-cell adherens junction; cytoplasm; plasma membrane
Biological Process: cell-cell adhesion; hair cycle process; keratinization; negative regulation of catagen; negative regulation of transforming growth factor-beta2 production; positive regulation of insulin-like growth factor receptor signaling pathway; positive regulation of melanin biosynthetic process; positive regulation of monophenol monooxygenase activity; retinal homeostasis; Wnt receptor signaling pathway through beta-catenin
Research Articles on Cdh3
1. P-cadherin is a direct PAX3-FOXO1A transcriptional target involved in Alveolar rhabdomyosarcoma aggressiveness.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
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