MYL3, Monoclonal Antibody

Monoclonal MYL3; Anti-MYL3; VLC1; MYL-3; Myosin Light Chain 3 Alkali Ventricular Skeletal Slow; MLC1V; CMH8; MYL 3; MYL3

For Research Use Only. Not for use in diagnostic procedures.

Monoclonal

IgG1

7C1

Mouse

Supplied as a liquid in ascitic fluid containing 0.03% sodium azide.

1.0 mg/ml (lot specific)

Store at 4 degree C for short term storage. Store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

Small volumes of anti-MYL3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Mouse monoclonal MYL3 antibody

Cell Biology

ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)

ELISA: 1:10,000
IHC: 1:200-1:1000
WB: 1:500-1:2000

Western Blot showing MYL3 (1) and MYL2 (2) antibody used against rat fetal heart tissues lysate.

Immunohistochemical analysis of paraffin-embedded human skeletal muscle (left) and cardiac muscle (right) using MYL3 antibody with DAB staining.

21,932 Da

myosin, light chain 3, alkali; ventricular, skeletal, slow

myosin light chain 3

Myosin light chain 3

CMLC1; MLC1SB  [Similar Products]

MYL3_HUMAN

MYL3 encodes myosin light chain 3, an alkali light chain also referred to in the literature as both the ventricular isoform and the slow skeletal muscle isoform. Mutations in MYL3 have been identified as a cause of mid-left ventricular chamber type hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]

MYL3: Regulatory light chain of myosin. Does not bind calcium. Defects in MYL3 are the cause of familial hypertrophic cardiomyopathy type 8 (CMH8). Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. CMH8 inheritance can be autosomal dominant or recessive.

Protein type: Motility/polarity/chemotaxis; Motor

Chromosomal Location of Human Ortholog: 3p21.3-p21.2

Cellular Component: I band; sarcomere; muscle myosin complex; cytosol; A band

Molecular Function: actin monomer binding; structural constituent of muscle; motor activity; myosin II heavy chain binding; calcium ion binding

Biological Process: skeletal muscle development; metabolic process; positive regulation of ATPase activity; regulation of striated muscle contraction; ventricular cardiac muscle morphogenesis; regulation of the force of heart contraction; cardiac muscle contraction; muscle filament sliding

Disease: Cardiomyopathy, Familial Hypertrophic, 8

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