BMP-10, Polyclonal Antibody

bone morphogenetic protein 10

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

Affinity Purification

1mg/mL (lot specific)

Store at -20 degree C. Avoid freeze / thaw cycles.

Manufactured in an ISO 9001:2015 Certified Laboratory.

Small volumes of anti-BMP-10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

BMP10 (Bone Morphogenetic Protein 10) is a Protein Coding gene. Diseases associated with BMP10 include Feingold Syndrome and Right Atrial Isomerism. Among its related pathways are GPCR Pathway and PEDF Induced Signaling. GO annotations related to this gene include cytokine activity and hormone activity. An important paralog of this gene is GDF2.This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which binds to the activin receptor-like kinase 1 (ALK1) and plays important roles in cardiovascular development including cardiomyocyte proliferation and regulation of heart size, closure of the ductus arteriosus, angiogenesis and ventricular trabeculation.

Western Blot (WB), ELISA (EIA)

WB: 1:500-2000
ELISA: 1:10000-20000

Western Blot analysis of Mouse brain, Mouse lung using BMP-10 Polyclonal Antibody at dilution of 1:1000.

Calculated Molecular Weight: 48kDa
Observed Molecular Weight: 48kDa

bone morphogenetic protein 10

bone morphogenetic protein 10

Bone morphogenetic protein 10

BMP-10  [Similar Products]

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which binds to the activin receptor-like kinase 1 (ALK1) and plays important roles in cardiovascular development including cardiomyocyte proliferation and regulation of heart size, closure of the ductus arteriosus, angiogenesis and ventricular trabeculation. [provided by RefSeq, Aug 2016]

BMP10: Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. Belongs to the TGF-beta family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 2p13.3

Cellular Component: cell surface; cytoplasm; extracellular region; extracellular space; Z disc

Molecular Function: cytokine activity; growth factor activity; hormone activity; protein binding; receptor serine/threonine kinase binding; telethonin binding; transforming growth factor beta receptor binding

Biological Process: activin receptor signaling pathway; ***** heart development; atrial cardiac muscle morphogenesis; BMP signaling pathway; cardiac muscle cell proliferation; cell adhesion; negative regulation of cell growth; negative regulation of cell migration; positive regulation of cardiac muscle cell proliferation; positive regulation of transcription, DNA-templated; regulation of apoptosis; regulation of MAPK cascade; sarcomere organization; ventricular cardiac muscle cell development; ventricular cardiac muscle tissue morphogenesis

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