Product Name
BMPR1A, Monoclonal Antibody
Full Product Name
Mouse Monoclonal Antibody to BMPR1A
Product Synonym Names
ALK3; SKR5; CD292; ACVRLK3; 10q23del
Product Gene Name
anti-BMPR1A antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P36894
Other Notes
Small volumes of anti-BMPR1A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-BMPR1A antibody
Western Blot (WB), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)
Application Notes for anti-BMPR1A antibody
Western blot using Recombinant protein
Western blot using Transfection expressed protein
NCBI/Uniprot data below describe general gene information for BMPR1A. It may not necessarily be applicable to this product.
NCBI Accession #
NP_004320.2
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NCBI GenBank Nucleotide #
NM_004329.2
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UniProt Primary Accession #
P36894
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UniProt Secondary Accession #
Q8NEN8; A8K6U9[Other Products]
UniProt Related Accession #
P36894[Other Products]
NCBI Official Full Name
bone morphogenetic protein receptor type-1A
NCBI Official Synonym Full Names
bone morphogenetic protein receptor type 1A
NCBI Official Symbol
BMPR1A [Similar Products]
NCBI Official Synonym Symbols
ALK3; SKR5; CD292; ACVRLK3; 10q23del
[Similar Products]
NCBI Protein Information
bone morphogenetic protein receptor type-1A
UniProt Protein Name
Bone morphogenetic protein receptor type-1A
UniProt Synonym Protein Names
Activin receptor-like kinase 3; ALK-3; Serine/threonine-protein kinase receptor R5; SKR5; CD_antigen: CD292
Protein Family
Bone morphogenetic protein receptor
UniProt Gene Name
BMPR1A [Similar Products]
UniProt Synonym Gene Names
ACVRLK3; ALK3; BMP type-1A receptor; BMPR-1A; ALK-3; SKR5 [Similar Products]
NCBI Summary for BMPR1A
The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. [provided by RefSeq, Jul 2008]
UniProt Comments for BMPR1A
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6.
Research Articles on BMPR1A
1. both bone morphogenetic protein 2 (BMP2) and BMP6 are proangiogenic in vitro and ex vivo and that the BMP type I receptors, activin receptor-like kinase 3 (ALK3) and ALK2, play crucial and distinct roles in this process.
Precautions
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Disclaimer
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