Natural Resistance-Associated Macrophage Protein 1 (NRAMP-1), ELISA Kit

For Research Use Only. Not for use in diagnostic procedures.

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Small volumes of NRAMP-1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS779989 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Natural Resistance-Associated Macrophage Protein 1 (NRAMP-1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing NRAMP-1. The ELISA analytical biochemical technique of the MBS779989 kit is based on NRAMP-1 antibody-NRAMP-1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect NRAMP-1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, NRAMP-1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

47,292 Da

solute carrier family 11 member 1

natural resistance-associated macrophage protein 1

Natural resistance-associated macrophage protein 1

LSH; NRAMP; NRAMP1; NRAMP 1  [Similar Products]

This gene is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family and encodes a multi-pass membrane protein. The protein functions as a divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Mutations in this gene have been associated with susceptibility to infectious diseases such as tuberculosis and leprosy, and inflammatory diseases such as rheumatoid arthritis and Crohn disease. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]

Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe2+ and Mn2+, cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes.

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