Product Name
3 beta-hydroxysteroid dehydrogenase type 4 (Hsd3b4), Recombinant Protein
Full Product Name
Recombinant Mouse 3 beta-hydroxysteroid dehydrogenase type 4 (Hsd3b4)
Product Gene Name
Hsd3b4 recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
2-373aa; full length protein
Sequence
PGWSCLVTGA GGFLGQRIVR MLVQEEELQE IRALFRTFGR KQEEELSKLQ TKTKVTVLKG DILDAQCLKR ACQGMSAVIH TAAAIDPLGA ASRQTILDVN LKGTQLLLDA CVEANVPTFI YSSSVLVAGP NSYKEIILNA HEEEHHESTW SNPYPYSKKM AEKAVLAANG SILKNGGTLH TCALRLSFIY GEECQVTSTT VKTALKNNSI IKKNATFSIA NPVYVGNAAW AHILAARSLQ DPKKSPSIQG QFYYITDDTP HQSYDDLKCT LSKEWGLRLD TSWSLPLPLL YWLAFLLETV SFLLRPVYNY RPPFNRLLIT VLNSVFTFSY KKAQRDLGYE PLVSWEEAKQ KTSEWIGTLV MQHREIGNKK SQ
3D Structure
ModBase 3D Structure for Q61767
Host
Cell Free Expression
Form/Format
Liquid containing glycerol
Storage Buffer
Tris-based buffer, 50% glycerol.
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Hsd3b4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for Hsd3b4 recombinant protein
Transmembrane Protein
Application Notes for Hsd3b4 recombinant protein
This is a recombinant transmembrane protein expressed in a cell-free expression system.
NCBI/Uniprot data below describe general gene information for Hsd3b4. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001104806.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001111336.1
[Other Products]
UniProt Primary Accession #
Q61767
[Other Products]
UniProt Related Accession #
Q61767[Other Products]
Molecular Weight
41,766 Da
NCBI Official Full Name
3 beta-hydroxysteroid dehydrogenase type 4
NCBI Official Synonym Full Names
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 4
NCBI Official Symbol
Hsd3b4 [Similar Products]
NCBI Protein Information
3 beta-hydroxysteroid dehydrogenase type 4
UniProt Protein Name
3 beta-hydroxysteroid dehydrogenase type 4
UniProt Synonym Protein Names
3 beta-hydroxysteroid dehydrogenase type IV; 3-beta-HSD IV; 3-beta-hydroxy-5-ene steroid dehydrogenase; NADPH-dependent 3-beta-hydroxy-Delta(5)-steroid dehydrogenase (EC:1.1.1.-); Progesterone reductase
Protein Family
3 beta-hydroxysteroid dehydrogenase
UniProt Gene Name
Hsd3b4 [Similar Products]
UniProt Synonym Gene Names
3-beta-HSD IV [Similar Products]
UniProt Entry Name
3BHS4_MOUSE
UniProt Comments for Hsd3b4
Hsd3b4: The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD IV can only catalyze the conversion of dihydrotestosterone to 5 alpha- androstanediol in the presence of the cofactor NADPH. Does not function as a isomerase. Belongs to the 3-beta-HSD family.
Protein type: Mitochondrial; Membrane protein, integral; EC 1.1.1.-
Cellular Component: intracellular membrane-bound organelle; mitochondrial inner membrane; mitochondrion
Molecular Function: 3-beta-hydroxy-delta5-steroid dehydrogenase activity; NAD binding; steroid binding
Research Articles on Hsd3b4
1. Data suggest that newly synthesized protein(s) are required for cAMP induction of Hsd3b4 and CYP17 mRNA levels (but not of CYP11A mRNA levels). [REVIEW]
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
