Product Name
ADH1A, cDNA Clone
Full Product Name
ADH1A cDNA Clone
Product Gene Name
ADH1A cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgagcacag caggaaaagt aatcaaatgc aaagcagctg tgctatggga gttaaagaaa cccttttcca ttgaggaggt ggaggttgca cctcctaagg cccatgaagt tcgtattaag atggtggctg taggaatctg tggcacagat gaccacgtgg ttagtggtac catggtgacc ccacttcctg tgattttagg ccatgaggca gccggcatcg tggagagtgt tggagaaggg gtgactacag tcaaaccagg tgataaagtc atcccactcg ctattcctca gtgtggaaaa tgcagaattt gtaaaaaccc ggagagcaac tactgcttga aaaacgatgt aagcaatcct caggggaccc tgcaggatgg caccagcagg ttcacctgca ggaggaagcc catccaccac ttccttggca tcagcacctt ctcacagtac acagtggtgg atgaaaatgc agtagccaaa attgatgcag cctcgcctct agagaaagtc tgtctcattg gctgtggatt ttcaactggt tatgggtctg cagtcaatgt tgccaaggtc accccaggct ctacctgtgc tgtgtttggc ctgggagggg tcggcctatc tgctattatg ggctgtaaag cagctggggc agccagaatc attgcggtgg acatcaacaa ggacaaattt gcaaaggcca aagagttggg tgccactgaa tgcatcaacc ctcaagacta caagaaaccc atccaggagg tgctaaagga aatgactgat ggaggtgtgg atttttcatt tgaagtcatc ggtcggcttg acaccatgat ggcttccctg ttatgttgtc atgaggcatg tggcacaagt gtcatcgtag gggtacctcc tgattcccaa aacctctcaa tgaaccctat gctgctactg actggacgta cctggaaggg agctattctt ggtggcttta aaagtaaaga atgtgtccca aaacttgtgg ctgattttat ggctaagaag ttttcattgg atgcattaat aacccatgtt ttaccttttg aaaaaataaa tgaaggattt gacctgcttc actctgggaa aagtatccgt accattctga tgttttga
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of ADH1A cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for ADH1A. It may not necessarily be applicable to this product.
NCBI Accession #
BC117442
[Other Products]
UniProt Secondary Accession #
Q17R68; A8K3E3[Other Products]
UniProt Related Accession #
P07327[Other Products]
Molecular Weight
39,859 Da
NCBI Official Full Name
Homo sapiens alcohol dehydrogenase 1A (class I), alpha polypeptide, mRNA
NCBI Official Synonym Full Names
alcohol dehydrogenase 1A (class I), alpha polypeptide
NCBI Official Symbol
ADH1A [Similar Products]
NCBI Official Synonym Symbols
ADH1
[Similar Products]
NCBI Protein Information
alcohol dehydrogenase 1A
UniProt Protein Name
Alcohol dehydrogenase 1A
UniProt Synonym Protein Names
Alcohol dehydrogenase subunit alpha
UniProt Gene Name
ADH1A [Similar Products]
UniProt Synonym Gene Names
ADH1 [Similar Products]
UniProt Entry Name
ADH1A_HUMAN
NCBI Summary for ADH1A
This gene encodes a member of the alcohol dehydrogenase family. The encoded protein is the alpha subunit of class I alcohol dehydrogenase, which consists of several homo- and heterodimers of alpha, beta and gamma subunits. Alcohol dehydrogenases catalyze the oxidation of alcohols to aldehydes. This gene is active in the liver in early fetal life but only weakly active in ***** liver. This gene is found in a cluster with six additional alcohol dehydrogenase genes, including those encoding the beta and gamma subunits, on the long arm of chromosome 4. Mutations in this gene may contribute to variation in certain personality traits and substance dependence. [provided by RefSeq, Nov 2010]
UniProt Comments for ADH1A
ADH1A: a member of the alcohol dehydrogenase family. The encoded protein is the alpha subunit of class I alcohol dehydrogenase, which consists of several homo- and heterodimers of alpha, beta and gamma subunits. Alcohol dehydrogenases catalyze the oxidation of alcohols to aldehydes. This gene is active in the liver in early fetal life but only weakly active in ***** liver. This gene is found in a cluster with six additional alcohol dehydrogenase genes, including those encoding the beta and gamma subunits, on the long arm of chromosome 4. Mutations in this gene may contribute to variation in certain personality traits and substance dependence. [provided by RefSeq, Nov 2010]
Protein type: Xenobiotic Metabolism - drug metabolism - cytochrome P450; Cofactor and Vitamin Metabolism - retinol; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Oxidoreductase; Xenobiotic Metabolism - metabolism by cytochrome P450; Amino Acid Metabolism - tyrosine; Transcription regulation; Lipid Metabolism - fatty acid; EC 1.1.1.1
Chromosomal Location of Human Ortholog: 4q23
Cellular Component: cytosol
Molecular Function: alcohol dehydrogenase activity; alcohol dehydrogenase activity, zinc-dependent; protein binding; retinol dehydrogenase activity
Biological Process: drug metabolic process; ethanol oxidation
Research Articles on ADH1A
1. Data indicate that the up-regulation of aldehyde dehydrogenase-1 (ALDH1) after neoadjuvant chemotherapy (NAC) predicts poor survival in locally advanced breast cancer.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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