Product Name
Nkx2-5, Blocking Peptide
Full Product Name
Mouse Nkx2-5 Blocking Peptide (Center)
Product Synonym Names
Homeobox protein Nkx-25; Cardiac-specific homeobox; Homeobox protein CSX; Homeobox protein NK-2 homolog E; Nkx2-5; Csx; Nkx-25; Nkx2e
Product Gene Name
Nkx2-5 blocking peptide
[Similar Products]
Product Synonym Gene Name
Csx; Nkx-2.5; Nkx2e[Similar Products]
Nkx2-5 peptide (MBS9229841) is used for blocking the activity of Nkx2-5 antibody (MBS9204436)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P42582
Specificity
The synthetic peptide sequence is selected from aa 98-113 of HUMAN Nkx2-5
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Cellular Location
Nucleus.
Tissue Location
Predominantly in the ***** and embryonic heart, and to a lesser extent in lingual muscle, spleen and stomach
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Other Notes
Small volumes of Nkx2-5 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
Nkx2-5 blocking peptide
Implicated in commitment to and/or differentiation of the myocardial lineage. Acts as a transcriptional activator of ANF in cooperation with GATA4. It is transcriptionally controlled by PBX1 and acts as a transcriptional repressor of CDKN2B. Together with PBX1, it is required for spleen development through a mechanism that involves CDKN2B repression.
NCBI/Uniprot data below describe general gene information for Nkx2-5. It may not necessarily be applicable to this product.
NCBI Accession #
P42582.1
[Other Products]
UniProt Primary Accession #
P42582
[Other Products]
UniProt Secondary Accession #
P97335[Other Products]
UniProt Related Accession #
P42582[Other Products]
Molecular Weight
34,163 Da
NCBI Official Full Name
Homeobox protein Nkx-2.5
NCBI Official Synonym Full Names
NK2 homeobox 5
NCBI Official Symbol
Nkx2-5 [Similar Products]
NCBI Official Synonym Symbols
Csx; Nkx2.5; tinman; Nkx-2.5
[Similar Products]
NCBI Protein Information
homeobox protein Nkx-2.5
UniProt Protein Name
Homeobox protein Nkx-2.5
UniProt Synonym Protein Names
Cardiac-specific homeobox; Homeobox protein CSX; Homeobox protein NK-2 homolog E
Protein Family
Homeobox protein
UniProt Gene Name
Nkx2-5 [Similar Products]
UniProt Synonym Gene Names
Csx; Nkx-2.5; Nkx2e [Similar Products]
UniProt Entry Name
NKX25_MOUSE
UniProt Comments for Nkx2-5
NKX2-5: Implicated in commitment to and/or differentiation of the myocardial lineage. Acts as a transcriptional activator of ANF in cooperation with GATA4. Interacts with HIPK1 and HIPK2, but not HIPK3. Interacts with the C-terminal zinc finger of GATA4 through its homeobox domain. Also interacts with JARID2 which represses its ability to activate transcription of ANF. Interacts with FBLIM1. Expressed only in the heart. Belongs to the NK-2 homeobox family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA-binding
Cellular Component: cytoplasm; nucleus; transcription factor complex
Molecular Function: chromatin binding; DNA binding; histone deacetylase binding; protein binding; protein heterodimerization activity; protein homodimerization activity; RNA polymerase II transcription factor activity, enhancer binding; sequence-specific DNA binding; transcription factor activity; transcription factor binding
Biological Process: ***** heart development; atrial cardiac muscle cell development; BMP signaling pathway; cardiac muscle cell differentiation; cardiac muscle cell proliferation; cardiac muscle contraction; cardiac muscle development; cardiac muscle morphogensis; cell differentiation; embryonic heart tube development; endoderm development; heart contraction; heart development; heart looping; heart morphogenesis; hemopoiesis; negative regulation of apoptosis; negative regulation of transcription from RNA polymerase II promoter; pharyngeal system development; positive regulation of cardioblast differentiation; positive regulation of cell proliferation; positive regulation of heart contraction; positive regulation of neuron differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of cardiac muscle cell proliferation; regulation of transcription from RNA polymerase II promoter; sarcomere organization; spleen development; thyroid gland development; tongue development; vasculogenesis; ventricular cardiac muscle cell development; ventricular cardiac myofibril development; Wnt receptor signaling pathway through beta-catenin
Research Articles on Nkx2-5
1. Sequential binding of MEIS1 and NKX2-5 on the Popdc2 gene demonstrate a mechanism for spatiotemporal regulation of enhancers during cardiogenesis.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
