Product Name
Desmoglein 2 (DSG2), Monoclonal Antibody
Full Product Name
Desmoglein 2 antibody
Product Synonym Names
Monoclonal Desmoglein 2; Anti-Desmoglein 2
Product Gene Name
anti-DSG2 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q14126
Species Reactivity
Human desmoglein 2
Purity/Purification
Culture supernatant
Form/Format
Hybridoma culture supernatant with 0.09% NaN3
Biological Significance
The desmogleins are a family of cadherins consisting of proteins DSG1, DSG2, DSG3, and DSG4. They play a role in the formation of desmosomes that join cells to one another.
Biohazard Information
This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
Immunogen
Desmoglein 2 antibody was raised in mouse using recombinant peptide (220 amino acids of 2nd and 3rd extracellular repeat domain) as the immunogen.
Preparation and Storage
Store at 4 degree C.
Other Notes
Small volumes of anti-DSG2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-DSG2 antibody
Mouse monoclonal Desmoglein 2 antibody
Product Categories/Family for anti-DSG2 antibody
Cell Biology
Applications Tested/Suitable for anti-DSG2 antibody
ELISA (EIA), Immunohistochemistry (IHC) Formalin/Paraffin, Western Blot (WB)
NCBI/Uniprot data below describe general gene information for DSG2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001934.2
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NCBI GenBank Nucleotide #
NM_001943.3
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UniProt Primary Accession #
Q14126
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UniProt Secondary Accession #
Q4KKU6[Other Products]
UniProt Related Accession #
Q14126[Other Products]
Molecular Weight
122,294 Da[Similar Products]
NCBI Official Full Name
desmoglein-2 preproprotein
NCBI Official Synonym Full Names
desmoglein 2
NCBI Official Symbol
DSG2 [Similar Products]
NCBI Official Synonym Symbols
HDGC; CDHF5; ARVC10; ARVD10; CMD1BB
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NCBI Protein Information
desmoglein-2
UniProt Protein Name
Desmoglein-2
UniProt Synonym Protein Names
Cadherin family member 5; HDGC
Protein Family
Desmoglein
UniProt Gene Name
DSG2 [Similar Products]
UniProt Synonym Gene Names
CDHF5 [Similar Products]
UniProt Entry Name
DSG2_HUMAN
NCBI Summary for DSG2
Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. This gene product is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This second family member is expressed in colon, colon carcinoma, and other simple and stratified epithelial-derived cell lines. Mutations in this gene have been associated with arrhythmogenic right ventricular dysplasia, familial, 10. [provided by RefSeq, Jul 2008]
UniProt Comments for DSG2
DSG2: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Defects in DSG2 are the cause of familial arrhythmogenic right ventricular dysplasia type 10 (ARVD10); also known as arrhythmogenic right ventricular cardiomyopathy 10 (ARVC10). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall. Genetic variations in DSG2 are the cause of susceptibility to cardiomyopathy dilated type 1BB (CMD1BB). A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
Protein type: Cell adhesion; Calcium-binding; Membrane protein, integral
Chromosomal Location of Human Ortholog: 18q12.1
Cellular Component: desmosome; cell surface; apical plasma membrane; plasma membrane; integral to membrane; intercellular junction; lateral plasma membrane
Molecular Function: calcium ion binding
Biological Process: maternal process involved in pregnancy; apoptosis; homophilic cell adhesion; cell adhesion; response to progesterone stimulus; cell structure disassembly during apoptosis
Disease: Cardiomyopathy, Dilated, 1bb; Arrhythmogenic Right Ventricular Dysplasia, Familial, 10
Research Articles on DSG2
1. Data demonstrate that partner desmosomal cadherins Dsg2 and Dsc2 play opposing roles in controlling colonic carcinoma cell proliferation through differential effects on EGFR signaling.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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