protein phosphatase 1, regulatory (inhibitor) subunit 13 like, ELISA Kit

Human RelA-associated inhibitor (PPP1R13L) ELISA kit; IASPP; NKIP1; RAI; NFkB interacting protein 1; RelA-associated inhibitor; inhibitor of apoptosis stimulating protein of p53; protein phosphatase 1; regulatory subunit 13 like; protein phosphatase 1; regulatory (inhibitor) subunit 13 like

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of PPP1R13L elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9328453 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the protein phosphatase 1, regulatory (inhibitor) subunit 13 like (PPP1R13L) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing PPP1R13L. The ELISA analytical biochemical technique of the MBS9328453 kit is based on PPP1R13L antibody-PPP1R13L antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect PPP1R13L antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, PPP1R13L. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

89,091 Da

protein phosphatase 1, regulatory subunit 13 like

relA-associated inhibitor; protein iASPP; PPP1R13B-like protein; retinoic acid induced 4; inhibitor of ASPP protein; NFkB interacting protein 1; NFkB-interacting protein 1; inhibitor of apoptosis stimulating protein of p53; protein phosphatase 1, regulatory (inhibitor) subunit 13 like

RelA-associated inhibitor

IASPP; NKIP1; PPP1R13BL; RAI; Protein iASPP  [Similar Products]

IASPP_HUMAN

IASPP is one of the most evolutionarily conserved inhibitors of p53 (TP53; MIM 191170), whereas ASPP1 (MIM 606455) and ASPP2 (MIM 602143) are activators of p53.[supplied by OMIM, Mar 2008]

PPP1R13L: an oncoprotein that interacts with and inhibits NF-kappaB, Sp1 and p53. Plays a central role in regulation of apoptosis and transcription. May inhibit p53 by preventing its association with ASPP1 or ASPP2, thereby suppressing the subsequent activation of apoptosis. Required for neuronal survival after axonal injury. Two alternatively spliced isoforms have been described. Isoform 1 is preferrentially found in the cytoplasm; isoform 2 is nuclear.

Protein type: Phosphatase, regulatory subunit; Apoptosis; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 19q13.32

Cellular Component: intercellular bridge; cytoplasm; nucleus; cell junction

Molecular Function: identical protein binding; protein binding; transcription factor binding; transcription corepressor activity

Biological Process: transcription, DNA-dependent; apoptosis; multicellular organism growth; multicellular organismal homeostasis; negative regulation of transcription from RNA polymerase II promoter; embryonic camera-type eye development; post-embryonic development; hair cycle; cardiac muscle contraction

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