Product Name
TCN2, cDNA Clone
Full Product Name
TCN2 cDNA Clone
Product Gene Name
TCN2 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgaggcacc ttggggcctt cctcttcctt ctgggggtcc tgggggccct cactgagatg tgtgaaatac cagagatgga cagccatctg gtagagaagt tgggccagca cctcttacct tggatggacc ggctttccct ggagcacttg aaccccagca tctatgtggg cctacgcctc tccagtctgc aggctgggac caaggaagac ctctacctgc acagcctcaa gcttggttac cagcagtgcc tcctagggtc tgccttcagc gaggatgacg gtgactgcca gggcaagcct tccatgggcc agctggccct ctacctgctc gctctcagag ccaactgtga gtttgtcagg ggccacaagg gggacaggct ggtctcacag ctcaaatggt tcctggagga tgagaagaga gccattgggc atgatcacaa gggccacccc cacactagct actaccagta tggcctgggc attctggccc tgtgtctcca ccagaagcgg gtccatgaca gcgtggtgga caaacttctg tatgctgtgg aacctttcca ccagggccac cattctgtgg acacagcagc catggcaggc ttggcattca cctgtctgaa gcgctcaaac ttcaaccctg gtcggagaca acggatcacc atggccatca gaacagtgca agaggagatc ttgaaggccc agacccccga gggccacttt gggaatgtct acagcacccc attggcatta cagttcctca tgacttcccc catgcgtggg gcagaactgg gaacagcatg tctcaaggcg agggttgctt tgctggccag tctgcaggat ggagccttcc agaatgctct catgatttcc cagctgctgc ccgttctgaa ccacaagacc tacattgatc tgatcttccc agactgtctg gcaccacgag tcatgttgga accagctgct gagaccattc ctcagaccca agagatcatc agtgtcacgc tgcaggtgct tagtctcttg ccgccgtaca gacagtccat ctctgttctg gccgggtcca ccgtggaaga tgtcctgaag aaggcccatg agttaggagg attcacatat gaaacacagg cctccttgtc aggcccctac ttaacctccg tgatggggaa agcggccgga gaaagggagt tctggcagct tctccgagac cccaacaccc cactgttgca aggtattgct gactacagac ccaaggatgg agaaaccatt gagctgaggc tggttagctg gtag
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of TCN2 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for TCN2. It may not necessarily be applicable to this product.
NCBI Accession #
BC001176
[Other Products]
UniProt Secondary Accession #
Q96FD4; Q9BVI8; Q9UCI5; Q9UCI6; Q9UDM0[Other Products]
UniProt Related Accession #
P20062; AAB25526[Other Products]
Molecular Weight
44,421 Da
NCBI Official Full Name
Homo sapiens transcobalamin II; macrocytic anemia, mRNA
NCBI Official Synonym Full Names
transcobalamin 2
NCBI Official Symbol
TCN2 [Similar Products]
NCBI Official Synonym Symbols
II; TC; TC2; TC-2; TCII; TC II; D22S676; D22S750
[Similar Products]
NCBI Protein Information
transcobalamin-2
UniProt Protein Name
Transcobalamin-2
UniProt Synonym Protein Names
Transcobalamin II; TC II; TCII
Protein Family
Transcobalamin
UniProt Gene Name
TCN2 [Similar Products]
UniProt Synonym Gene Names
TC2; TC-2; TC II; TCII [Similar Products]
UniProt Entry Name
TCO2_HUMAN
NCBI Summary for TCN2
This gene encodes a member of the vitamin B12-binding protein family. This family of proteins, alternatively referred to as R binders, is expressed in various tissues and secretions. This plasma protein binds cobalamin and mediates the transport of cobalamin into cells. This protein and other mammalian cobalamin-binding proteins, such as transcobalamin I and gastric intrisic factor, may have evolved by duplication of a common ancestral gene. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
UniProt Comments for TCN2
TCN2: Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells. Defects in TCN2 are the cause of transcobalamin II deficiency (TCN2 deficiency). This results in various forms of anemia. Belongs to the eukaryotic cobalamin transport proteins family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 22q12.2
Cellular Component: endosome; extracellular region; lysosomal lumen
Molecular Function: cobalamin binding
Biological Process: cobalamin metabolic process
Disease: Transcobalamin Ii Deficiency
Research Articles on TCN2
1. G polymorphism is negatively associated with Alzheimer's type dementia, suggesting a protective role against the disease in subjects with the 5, 10-methylenetetrahydrofolate reductase 1298AA genotype">TCN2 776C --> G polymorphism is negatively associated with Alzheimer's type dementia, suggesting a protective role against the disease in subjects with the 5, 10-methylenetetrahydrofolate reductase 1298AA genotype
Precautions
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Disclaimer
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