Full Product Name
ACO2, ID (Aconitate Hydratase, Mitochondrial, Citrate Hydro-lyase, Aconitase)
Product Synonym Names
Anti -ACO2, ID (Aconitate Hydratase, Mitochondrial, Citrate Hydro-lyase, Aconitase)
Product Gene Name
anti-ACO2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 22; NC_000022.10 (41865129..41924993). Location: 22q11.2-q13.31; 22q13.2
3D Structure
ModBase 3D Structure for Q99798
Specificity
Recognizes human ACO2.
Purity/Purification
Purified
Purified by ammonium sulfate precipitation.
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Immunogen
Synthetic peptide selected from the Center region of human ACO2 (KLH).
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-ACO2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ACO2 antibody
ACO2 belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. It was found to be one of the mitochondrial matrix proteins that are preferentially degraded by the serine protease 15(PRSS15), also known as Lon protease, after oxidative modification.
Product Categories/Family for anti-ACO2 antibody
Antibodies; Abs to Interferon
Applications Tested/Suitable for anti-ACO2 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-ACO2 antibody
Suitable for use in ELISA, Western Blot, and Immunohistochemistry.
Dilution: ELISA: 1:1,000
Western Blot: 1:50-1:100
Immunohistochemistry: 1:10-1:50
NCBI/Uniprot data below describe general gene information for ACO2. It may not necessarily be applicable to this product.
UniProt Primary Accession #
Q99798
[Other Products]
UniProt Secondary Accession #
O75809; Q5JZ41; Q6FHX0; Q8TAQ6[Other Products]
UniProt Related Accession #
Q71UF1; Q99798[Other Products]
Molecular Weight
85,425 Da[Similar Products]
NCBI Official Full Name
ACO2
NCBI Official Synonym Full Names
aconitase 2, mitochondrial
NCBI Official Symbol
ACO2 [Similar Products]
NCBI Official Synonym Symbols
ACONM; MGC20605; MGC33908
[Similar Products]
NCBI Protein Information
aconitate hydratase, mitochondrial; OTTHUMP00000165920; OTTHUMP00000165921; citrate hydro-lyase
UniProt Protein Name
Aconitate hydratase, mitochondrial
UniProt Synonym Protein Names
Citrate hydro-lyase
Protein Family
Aconitate hydratase
UniProt Gene Name
ACO2 [Similar Products]
UniProt Entry Name
ACON_HUMAN
NCBI Summary for ACO2
The protein encoded by this gene belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. This protein is encoded in the nucleus and functions in the mitochondrion. It was found to be one of the mitochondrial matrix proteins that are preferentially degraded by the serine protease 15(PRSS15), also known as Lon protease, after oxidative modification. [provided by RefSeq]
UniProt Comments for ACO2
ACO2: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate. Monomer. Belongs to the aconitase/IPM isomerase family.
Protein type: Lyase; Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glyoxylate and dicarboxylate; Mitochondrial; EC 4.2.1.3
Chromosomal Location of Human Ortholog: 22q13.2
Cellular Component: mitochondrion; mitochondrial matrix; nucleus
Molecular Function: 4 iron, 4 sulfur cluster binding; iron ion binding; aconitate hydratase activity; 3 iron, 4 sulfur cluster binding
Biological Process: isocitrate metabolic process; cellular metabolic process; generation of precursor metabolites and energy; tricarboxylic acid cycle; citrate metabolic process
Disease: Infantile Cerebellar-retinal Degeneration; Optic Atrophy 8
Research Articles on ACO2
1. these results suggest that p53 downregulation of mACON gene expression in human prostate carcinoma cells may not occur through the putative consensus p53 response elements found within the mACON promoter.
Precautions
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