Full Product Name
AKAP5 Antibody
Product Synonym Names
A-kinase anchor protein 5; A-kinase anchor protein 79 kDa; AKAP 79; cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein; H21; AKAP5; AKAP79
Product Gene Name
anti-AKAP5 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P24588
Specificity
AKAP5 antibody detects endogenous levels of total AKAP5 protein.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen
The antiserum was produced against synthesized peptide derived from N-terminal of human AKAP5.
Preparation and Storage
Store at-20 degree C for 1 year.
Other Notes
Small volumes of anti-AKAP5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-AKAP5 antibody
Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
Applications Tested/Suitable for anti-AKAP5 antibody
Western Blot (WB), Immunofluorescence (IF), ELISA (EIA)
Application Notes for anti-AKAP5 antibody
WB: 1:500~1:1000
IF: 1:100~1:500
ELISA: 1:10000
Testing Data of anti-AKAP5 antibody
Western Blot (WB) of anti-AKAP5 antibody
Peptide-+ Western blot analysis of extracts from HepG2 cells, HeLa cells and COLO205 cells, using AKAP5 antibody. Immunofluorescence analysis of HeLa cells, using AKAP5 antibody.
NCBI/Uniprot data below describe general gene information for AKAP5. It may not necessarily be applicable to this product.
NCBI Accession #
NP_004848.3
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NCBI GenBank Nucleotide #
NM_004857.3
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UniProt Primary Accession #
P24588
[Other Products]
UniProt Secondary Accession #
A2RRB8[Other Products]
UniProt Related Accession #
P24588[Other Products]
Molecular Weight
47,088 Da
NCBI Official Full Name
A-kinase anchor protein 5
NCBI Official Synonym Full Names
A-kinase anchoring protein 5
NCBI Official Symbol
AKAP5 [Similar Products]
NCBI Official Synonym Symbols
H21; AKAP75; AKAP79
[Similar Products]
NCBI Protein Information
A-kinase anchor protein 5
UniProt Protein Name
A-kinase anchor protein 5
UniProt Synonym Protein Names
A-kinase anchor protein 79 kDa; AKAP 79; H21; cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein
Protein Family
A-kinase anchor protein
UniProt Gene Name
AKAP5 [Similar Products]
UniProt Synonym Gene Names
AKAP79; AKAP-5; AKAP 79 [Similar Products]
NCBI Summary for AKAP5
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to the RII-beta regulatory subunit of PKA, and also to protein kinase C and the phosphatase calcineurin. It is predominantly expressed in cerebral cortex and may anchor the PKA protein at postsynaptic densities (PSD) and be involved in the regulation of postsynaptic events. It is also expressed in T lymphocytes and may function to inhibit interleukin-2 transcription by disrupting calcineurin-dependent dephosphorylation of NFAT. [provided by RefSeq, Jul 2008]
UniProt Comments for AKAP5
May anchor the PKA protein to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors. Association with to the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade.
Product References and Citations for anti-AKAP5 antibody
Carr D.W., J. Biol. Chem. 267:16816-16823(1992). Hirsch A.H., J. Biol. Chem. 267:2131-2134(1992).
Research Articles on AKAP5
1. Studies indicate the importance of the AKAP79/PP2B/protein kinase A complex's role in synaptic long-term depression in the CA1 region of the hippocampus.
Precautions
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Disclaimer
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