Core Binding Factor beta, Monoclonal Antibody

Anti -Core Binding Factor beta (CBFb, PEBP2B)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 19; NC_005118.2 (34985879..35029446). Location: 19q11

Monoclonal

IgG1

8C84

Mouse

Recognizes human Core Binding Factor beta.

Affinity Purified
Purified by Protein G affinity chromatography.

Supplied as a liquid in PBS, pH 7.4, 1% BSA, 0.05% sodium azide.

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 

Small volumes of anti-Cbfb antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is a non-DNA binding regulatory subunit; it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. Alternative splicing generates two mRNA variants, each encoding a distinct carboxyl terminus. In some cases, a pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript consisting of the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain 11. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Two transcript variants encoding different isoforms have been found for this gene.

Antibodies; Abs to Binding Proteins

Western Blot (WB), Immunocytochemistry (ICC), Gel Shift Assay (GS/EMSA)

Suitable for use in Western Blot, Dot Blot and Immunocytochemistry.
Dilution: Western Blot: 0.2-2ug/ml

21,517 Da[Similar Products]

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