Product Name
FOXRED1, cDNA Clone
Full Product Name
FOXRED1 cDNA Clone
Product Gene Name
FOXRED1 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgattcgga gggttctgcc gcacggcatg ggccggggcc tcttgacccg gaggccaggc acgcgcagag gaggcttttc tctggactgg gatggaaagg tgtctgagat taagaagaag atcaagtcga tcctgcctgg aaggtcctgt gatctactgc aagacaccag ccacctgcct cccgagcact cggatgtggt gatcgtggga ggtggggtgc ttggcttgtc tgtggcctat tggctgaaga agctggagag cagacgaggt gctattcgag tgctagtggt ggaacgggac cacacgtatt cacaggcctc cactgggctc tcagtaggtg ggatttgtca gcagttctca ttgcctgaga acatccagct ctccctcttt tcagccagct ttctacggaa catcaatgag tacctggccg tagtcgatgc tcctcccctg gacctccggt tcaacccctc gggctacctc ttgctggctt cagaaaagga tgctgcagcc atggagagca acgtgaaagt gcagaggcag gagggagcca aagtttctct gatgtctcct gatcagcttc ggaacaagtt tccctggata aacacagagg gagtggcttt ggcgtcttat gggatggagg acgaaggttg gtttgacccc tggtgtctgc tccaggggct tcggcgaaag gtccagtcct tgggagtcct tttctgccag ggagaggtga cacgttttgt ctcttcatct caacgcatgt tgaccacaga tgacaaagcg gtggtcttga aaaggatcca tgaagtccat gtgaagatgg accgcagcct ggagtaccag cctgtggaat gcgccattgt gatcaacgca gccggagcct ggtctgcgca aatcgcagca ctggctggtg ttggagaggg gccgcctggc accctgcagg gcaccaagct acctgtggag ccgaggaaaa ggtatgtgta tgtgtggcac tgcccccagg gaccaggcct agagactccg cttgttccag acaccagtgg agcctatttt cgccgggaag gattaggtag caactaccta ggtggtcgta gccccactga gcaggaagaa ccggacccgg cgaacctgga agtggaccat gatttcttcc aggacaaggt gtggccccat ttggccctga gggtcccagc ttttgagact ctgaaggttc agagcgcctg ggccggctat tacgactaca acacctttga ccagaatggc gtggtgggcc cccacccgct agttgtcaac atgtactttg ctactggctt cagtggtcac gggctccagc aggcccctgg cattgggcga gctgtagcag agatggtact gaagggcagg ttccagacca tcgacctgag ccccttcctc tttacccgct tttacttggg agagaagatc caggagaaca acatcatctg a
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of FOXRED1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for FOXRED1. It may not necessarily be applicable to this product.
NCBI Accession #
BC013902
[Other Products]
UniProt Secondary Accession #
Q71MG0; Q9BU39; Q9UKY9; B3KN84; B4DHU2[Other Products]
UniProt Related Accession #
Q96CU9[Other Products]
Molecular Weight
52,104 Da
NCBI Official Full Name
Homo sapiens FAD-dependent oxidoreductase domain containing 1, mRNA
NCBI Official Synonym Full Names
FAD dependent oxidoreductase domain containing 1
NCBI Official Symbol
FOXRED1 [Similar Products]
NCBI Official Synonym Symbols
H17; FP634
[Similar Products]
NCBI Protein Information
FAD-dependent oxidoreductase domain-containing protein 1
UniProt Protein Name
FAD-dependent oxidoreductase domain-containing protein 1
Protein Family
FAD-dependent oxidoreductase domain-containing protein
UniProt Gene Name
FOXRED1 [Similar Products]
UniProt Entry Name
FXRD1_HUMAN
NCBI Summary for FOXRED1
This gene encodes a protein that contains a FAD-dependent oxidoreductase domain. The encoded protein is localized to the mitochondria and may function as a chaperone protein required for the function of mitochondrial complex I. Mutations in this gene are associated with mitochondrial complex I deficiency. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]
UniProt Comments for FOXRED1
FOXRED1: Defects in FOXRED1 are a cause of mitochondrial complex I deficiency (MT-C1D). A disorder of the mitochondrial respiratory chain that causes a wide range of clinical manifestations from lethal neonatal disease to *****-onset neurodegenerative disorders. Phenotypes include macrocephaly with progressive leukodystrophy, non-specific encephalopathy, cardiomyopathy, myopathy, liver disease, Leigh syndrome, Leber hereditary optic neuropathy, and some forms of Parkinson disease. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Mitochondrial
Chromosomal Location of Human Ortholog: 11q24.2
Cellular Component: mitochondrial inner membrane; mitochondrial respiratory chain complex I; mitochondrion
Biological Process: mitochondrial respiratory chain complex I assembly
Disease: Leigh Syndrome; Mitochondrial Complex I Deficiency
Research Articles on FOXRED1
1. Loss of FOXRED1, coupled with protein, choline and/or folate-deficient diets results in the depletion of glutathione, the dysregulation of nitric oxide metabolism and the peroxynitrite-mediated inactivation of complex I.
Precautions
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Disclaimer
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