A Disintegrin And Metalloproteinase With Thrombospondin 9 (ADAMTS9), Antibody P

For Research Use Only. Not for use in diagnostic procedures.

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Enzyme & Kinase

ELISA (EIA), Chemiluminescence Immunoassays (CLIA), ELISPOT, Luminex

213,420 Da

ADAM metallopeptidase with thrombospondin type 1 motif 9

A disintegrin and metalloproteinase with thrombospondin motifs 9

A disintegrin and metalloproteinase with thrombospondin motifs 9

KIAA1312; ADAM-TS 9; ADAM-TS9; ADAMTS-9  [Similar Products]

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. Members of the ADAMTS family have been implicated in the cleavage of proteoglycans, the control of organ shape during development, and the inhibition of angiogenesis. This gene is localized to chromosome 3p14.3-p14.2, an area known to be lost in hereditary renal tumors. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Jan 2016]

Cleaves the large aggregating proteoglycans, aggrecan (at the '1838-Glu-|-Ala-1839' site) and versican (at the '1428-Glu-|-Ala-1429' site). Has a protease-independent function in promoting the transport from the endoplasmic reticulum to the Golgi apparatus of a variety of secretory cargos.

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