Full Product Name
STRA6 Rabbit Polyclonal
Product Gene Name
anti-STRA6 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Purity/Purification
>=95% as determined by SDS-PAGE
Immunogen Affinity Purified
Immunogen
Stimulated by retinoic acid gene 6 homolog (Mouse)
Preparation and Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-STRA6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-STRA6 antibody
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for STRA6. It may not necessarily be applicable to this product.
NCBI Accession #
AAQ89447.1
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UniProt Secondary Accession #
Q6PJF8; Q71RB9; Q7L9G1; Q7Z3U9; Q8TB21; A8K7F1; B7Z5M9; B7Z862; D3DW54; F5GYI8; I3L1G8[Other Products]
UniProt Related Accession #
Q9BX79[Other Products]
Molecular Weight
75,192 Da
NCBI Official Full Name
STRA6
NCBI Official Synonym Full Names
stimulated by retinoic acid 6
NCBI Official Symbol
STRA6 [Similar Products]
NCBI Official Synonym Symbols
MCOPS9; MCOPCB8; PP14296
[Similar Products]
NCBI Protein Information
stimulated by retinoic acid gene 6 protein homolog
UniProt Protein Name
Stimulated by retinoic acid gene 6 protein homolog
Protein Family
Stimulated by retinoic acid gene 6 protein
UniProt Gene Name
STRA6 [Similar Products]
UniProt Entry Name
STRA6_HUMAN
NCBI Summary for STRA6
The protein encoded by this gene is a membrane protein involved in the metabolism of retinol. The encoded protein acts as a receptor for retinol/retinol binding protein complexes. This protein removes the retinol from the complex and transports it across the cell membrane. Defects in this gene are a cause of syndromic microphthalmia type 9 (MCOPS9). Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
UniProt Comments for STRA6
STRA6: May act as a high-affinity cell-surface receptor for the complex retinol-retinol binding protein (RBP/RBP4). Acts by removing retinol from RBP/RBP4 and transports it across the plasma membrane, where it can be metabolized. This mechanism does not depend on endocytosis. Binds to RBP/RBP4 with high affinity. Increases cellular retinol uptake from the retinol-RBP complex. Defects in STRA6 are the cause of microphthalmia syndromic type 9 (MCOPS9); also called Matthew-Wood syndrome or Spear syndrome. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS9 is a rare clinical entity including as main characteristics anophthalmia or severe microphthalmia, and pulmonary hypoplasia or aplasia. Mutations in STRA6 may be a cause of isolated colobomatous microphthalmia, a disorder of the eye characterized by an abnormally small ocular globe. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 15q24.1
Cellular Component: integral to membrane; plasma membrane; protein complex
Molecular Function: receptor activity; vitamin transporter activity
Biological Process: adrenal gland development; alveolus development; artery morphogenesis; blood vessel development; cognition; developmental growth; digestive tract morphogenesis; ear development; embryonic gut development; feeding behavior; female genitalia development; heart development; kidney development; learning; lung development; neuromuscular process; nose morphogenesis; positive regulation of behavior; retinoid metabolic process; smooth muscle development; vitamin transport; vocal learning
Disease: Microphthalmia, Syndromic 9
Research Articles on STRA6
1. These data establish that holo-RBP and its receptor STRA6 are potent oncogenes and suggest that the pathway is a novel target for therapy of some human cancers.
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