Full Product Name
STRA6 antibody - N-terminal region
Product Gene Name
anti-STRA6 antibody
[Similar Products]
Product Synonym Gene Name
FLJ12541; MCOPS9; PP14296[Similar Products]
Antibody/Peptide Pairs
STRA6 peptide (MBS3234546) is used for blocking the activity of STRA6 antibody (MBS3209590)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
Synthetic peptide located within the following region: MSSQPAGNQT SPGATEDYSY GSWYIDEPQG GEELQPEGEV PSCHTSIPPG
3D Structure
ModBase 3D Structure for Q9BX79
Purity/Purification
Affinity Purified
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human STRA6
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-STRA6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-STRA6 antibody
This is a rabbit polyclonal antibody against STRA6. It was validated on Western Blot using a cell lysate as a positive control.
Target Description: STRA6 may act as a high-affinity cell-surface receptor for the complex retinol-retinol binding protein (RBP/RBP4). STRA6 acts by removing retinol from RBP/RBP4 and transports it across the plasma membrane, where it can be metabolized. This mechanism does not depend on endocytosis. STRA6 binds to RBP/RBP4 with high affinity. STRA6 increases cellular retinol uptake from the retinol-RBP complex.
Product Categories/Family for anti-STRA6 antibody
Polyclonal; Membrane Protein; DNA/RNA/Protein Interactions;
Applications Tested/Suitable for anti-STRA6 antibody
Western Blot (WB)
Western Blot (WB) of anti-STRA6 antibody
WB Suggested Anti-STRA6 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: HepG2 cell lysate
NCBI/Uniprot data below describe general gene information for STRA6. It may not necessarily be applicable to this product.
NCBI Accession #
NP_071764
[Other Products]
NCBI GenBank Nucleotide #
NM_022369
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UniProt Primary Accession #
Q9BX79
[Other Products]
UniProt Related Accession #
Q9BX79[Other Products]
NCBI Official Full Name
receptor for retinol uptake STRA6 isoform a
NCBI Official Synonym Full Names
stimulated by retinoic acid 6
NCBI Official Symbol
STRA6 [Similar Products]
NCBI Official Synonym Symbols
MCOPS9; MCOPCB8; PP14296
[Similar Products]
NCBI Protein Information
receptor for retinol uptake STRA6
UniProt Protein Name
Stimulated by retinoic acid gene 6 protein homolog
Protein Family
Stimulated by retinoic acid gene 6 protein
UniProt Gene Name
STRA6 [Similar Products]
UniProt Entry Name
STRA6_HUMAN
NCBI Summary for STRA6
The protein encoded by this gene is a membrane protein involved in the metabolism of retinol. The encoded protein acts as a receptor for retinol/retinol binding protein complexes. This protein removes the retinol from the complex and transports it across the cell membrane. Defects in this gene are a cause of syndromic microphthalmia type 9 (MCOPS9). Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
Research Articles on STRA6
1. Mutations in retinoic acid 6 gene (STRA6) have been reported in clinically diagnosed patients with MWS. Here we presented a case with MWS, who has characteristic findings of the syndrome as well as dextrocardia as an undescribed feature, and bilateral streak gonads which was described only in one patient previously. Molecular analysis showed a homozygous exonic missense mutation in the STRA6 gene.
Precautions
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Disclaimer
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