Full Product Name
PRPH2 Antibody
Product Gene Name
anti-PRPH2 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P23942
Other Notes
Small volumes of anti-PRPH2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for PRPH2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000313.2
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NCBI GenBank Nucleotide #
NM_000322.4
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UniProt Primary Accession #
P23942
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UniProt Secondary Accession #
Q5TFH5; Q6DK65[Other Products]
UniProt Related Accession #
P23942[Other Products]
Molecular Weight
39,186 Da
NCBI Official Full Name
peripherin-2
NCBI Official Synonym Full Names
peripherin 2
NCBI Official Symbol
PRPH2 [Similar Products]
NCBI Official Synonym Symbols
DS; RDS; RP7; rd2; AVMD; PRPH; AOFMD; CACD2; MDBS1; TSPAN22
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NCBI Protein Information
peripherin-2
UniProt Protein Name
Peripherin-2
UniProt Synonym Protein Names
Retinal degeneration slow protein; Tetraspanin-22; Tspan-22
Protein Family
Peripherin
UniProt Gene Name
PRPH2 [Similar Products]
UniProt Synonym Gene Names
PRPH; RDS; TSPAN22; Tspan-22 [Similar Products]
NCBI Summary for PRPH2
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein found in the outer segment of both rod and cone photoreceptor cells. It may function as an adhesion molecule involved in stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. This protein is essential for disk morphogenesis. Defects in this gene are associated with both central and peripheral retinal degenerations. Some of the various phenotypically different disorders are autosomal dominant retinitis pigmentosa, progressive macular degeneration, macular dystrophy and retinitis pigmentosa digenic. [provided by RefSeq, Jul 2008]
UniProt Comments for PRPH2
May function as an adhesion molecule involved in stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. It is essential for disk morphogenesis.
Research Articles on PRPH2
1. Multiple genes contributing to the retinal dystrophy genotypes within a family were discovered using retinal gene-targeted next-generation sequencing. Families with noted examples of phenotypic variation or apparent non-penetrant individuals may offer a clue to suspect complex inheritance.
Precautions
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Disclaimer
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