Activin A Receptor Type II B (ACVR2B), Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 8; NC_005107.3 (127294071..127331625). Location: 8q32

E Coli

> 95%

Supplied as lyophilized form in PBS,pH7.4, containing 5% sucrose, 0.01% sarcosyl.

Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.
Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.

Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.

Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.

Small volumes of ACVR2B recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

About the Marker: Effective Size Range: 10kDa to 70kDa.
Protein bands: 10kDa, 14kDa, 18kDa, 22kDa, 26kDa, 33kDa, 44kDa and70kDa.
Double intensity bands: The 26kDa, 18kDa, 10kDa bands are at doubleintensity to make location and size approximation of proteins of interestquick and easy.
Ready-to-use: No need to heat, dilute or add reducing agents before use.

SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)

17.5kDa

activin A receptor, type IIB

activin receptor type-2B; ACTR-IIB; activin receptor IIB; activin receptor type IIB; ActRIIB type II activin receptor B; Activine receptor 2b (transmembrane serine kinase)

Activin receptor type-2B

Actriib; ACTR-IIB  [Similar Products]

AVR2B_RAT

plays a role in reproductive physiology and endocrinology [RGD, Feb 2006]

ACVR2B: a tyrosine-kinase like receptor kinase of the STKR family. The holoreceptor receptor is a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. Each is composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic kinase domain. Type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptor kinases are apparently constitutively active. The IIB receptor displays a 3- to 4-fold higher affinity for activin A than the II receptor.

Protein type: Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; Kinase, protein; Membrane protein, integral; EC 2.7.11.30; TKL group; STKR family; Type2 subfamily

Cellular Component: protein complex; cell; cytoplasm; integral to membrane; plasma membrane; receptor complex

Molecular Function: protein serine/threonine kinase activity; transforming growth factor beta binding; growth factor binding; metal ion binding; protein serine/threonine/tyrosine kinase activity; activin binding; transmembrane receptor protein serine/threonine kinase activity; ATP binding; receptor signaling protein serine/threonine kinase activity

Biological Process: heart development; regulation of signal transduction; palate development; signal transduction; protein amino acid phosphorylation; post-embryonic development; BMP signaling pathway; anterior/posterior pattern formation; positive regulation of activin receptor signaling pathway; regulation of transcription, DNA-dependent; lymphangiogenesis; embryonic foregut morphogenesis; pancreas development; response to glucose stimulus; mesoderm development; kidney development; skeletal development; gastrulation with mouth forming second; positive regulation of bone mineralization; pattern specification process; odontogenesis of dentine-containing teeth; positive regulation of osteoblast differentiation; organ growth; skeletal morphogenesis; sexual reproduction; insulin secretion; activation of protein kinase activity; blood vessel remodeling; determination of left/right symmetry; lung development

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.