STRA6, Polyclonal Antibody

Protein A-Purified Rabbit Polyclonal Antibody (Pab)

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Small volumes of anti-STRA6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Developmental Biology; Metabolism; Signal Transduction; Stem Cells

Western Blot (WB), Immunohistochemistry (IHC)

WB ~~ 1:100-1:500
IHC ~~ 1:50

Tissue/cell:Placenta,primary antibody 1:300 overnight.

human kidney tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer (0.01M, pH 6.0), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum) at 37 degree C for 20 min; Incubation: Anti-STRA6 Polyclonal Antibody, Unconjugated 1:200, overnight at 4 degree C, followed by conjugation to the secondary antibody and DABstaining.

73503

stimulated by retinoic acid 6

stimulated by retinoic acid gene 6 protein homolog

Stimulated by retinoic acid gene 6 protein homolog

STRA6_HUMAN

The protein encoded by this gene is a membrane protein involved in the metabolism of retinol. The encoded protein acts as a receptor for retinol/retinol binding protein complexes. This protein removes the retinol from the complex and transports it across the cell membrane. Defects in this gene are a cause of syndromic microphthalmia type 9 (MCOPS9). Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

STRA6: May act as a high-affinity cell-surface receptor for the complex retinol-retinol binding protein (RBP/RBP4). Acts by removing retinol from RBP/RBP4 and transports it across the plasma membrane, where it can be metabolized. This mechanism does not depend on endocytosis. Binds to RBP/RBP4 with high affinity. Increases cellular retinol uptake from the retinol-RBP complex. Defects in STRA6 are the cause of microphthalmia syndromic type 9 (MCOPS9); also called Matthew-Wood syndrome or Spear syndrome. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS9 is a rare clinical entity including as main characteristics anophthalmia or severe microphthalmia, and pulmonary hypoplasia or aplasia. Mutations in STRA6 may be a cause of isolated colobomatous microphthalmia, a disorder of the eye characterized by an abnormally small ocular globe. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 15q24.1

Cellular Component: protein complex; plasma membrane; integral to membrane

Biological Process: developmental growth; phototransduction, visible light; blood vessel development; adrenal gland development; neuromuscular process; heart development; ear development; digestive tract morphogenesis; learning; vocal learning; female genitalia development; nose morphogenesis; smooth muscle development; positive regulation of behavior; artery morphogenesis; retinoic acid metabolic process; feeding behavior; kidney development; cognition; retinoid metabolic process; alveolus development; embryonic gut development; lung development

Disease: Microphthalmia, Syndromic 9

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