Product Name
MPZ, cDNA Clone
Full Product Name
MPZ cDNA Clone
Product Gene Name
MPZ cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgctccggg cccctgcccc tgccccagct atggctcctg gggctccctc atccagcccc agccctatcc tggctgtgct gctcttctct tctttggtgc tgtccccggc ccaggccatc gtggtttaca ccgacaggga ggtccatggt gctgtgggct cccgggtgac cctgcactgc tccttctggt ccagtgagtg ggtctcagat gacatctcct tcacctggcg ctaccagccc gaagggggca gagatgccat ttcgatcttc cactatgcca agggacaacc ctacattgac gaggtgggga ccttcaaaga gcgcatccag tgggtagggg accctcgctg gaaggatggc tccattgtca tacacaacct agactacagt gacaatggca cgttcacttg tgacgtcaaa aaccctccag acatagtggg caagacctct caggtcacgc tgtatgtctt tgaaaaagtg ccaactaggt acggggtcgt tctgggagct gtgatcgggg gtgtcctcgg ggtggtgctg ttgctgctgc tgcttttcta cgtggttcgg tactgctggc tacgcaggca ggcggccctg cagaggaggc tcagtgctat ggagaagggg aaattgcaca agccaggaaa ggacgcgtcg aagcgcgggc ggcagacgcc agtgctgtat gcaatgctgg accacagcag aagcaccaaa gctgtcagtg agaagaaggc caaggggctg ggggagtctc gcaaggataa gaaatag
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of MPZ cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for MPZ. It may not necessarily be applicable to this product.
NCBI Accession #
BC006491
[Other Products]
UniProt Secondary Accession #
Q16072; Q5VTH4; Q92677; Q9BR67[Other Products]
UniProt Related Accession #
P25189[Other Products]
Molecular Weight
34,387 Da
NCBI Official Full Name
Homo sapiens myelin protein zero, mRNA
NCBI Official Synonym Full Names
myelin protein zero
NCBI Official Symbol
MPZ [Similar Products]
NCBI Official Synonym Symbols
P0; CHM; DSS; MPP; CMT1; CMT1B; CMT2I; CMT2J; CMT4E; CMTDI3; CMTDID; HMSNIB
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NCBI Protein Information
myelin protein P0
UniProt Protein Name
Myelin protein P0
UniProt Synonym Protein Names
Myelin peripheral protein; MPP; Myelin protein zero
Protein Family
Myelin protein
UniProt Gene Name
MPZ [Similar Products]
UniProt Synonym Gene Names
MPP [Similar Products]
UniProt Entry Name
MYP0_HUMAN
NCBI Summary for MPZ
This gene is specifically expressed in Schwann cells of the peripheral nervous system and encodes a type I transmembrane glycoprotein that is a major structural protein of the peripheral myelin sheath. The encoded protein contains a large hydrophobic extracellular domain and a smaller basic intracellular domain, which are essential for the formation and stabilization of the multilamellar structure of the compact myelin. Mutations in this gene are associated with autosomal dominant form of Charcot-Marie-Tooth disease type 1 (CMT1B) and other polyneuropathies, such as Dejerine-Sottas syndrome (DSS) and congenital hypomyelinating neuropathy (CHN). A recent study showed that two isoforms are produced from the same mRNA by use of alternative in-frame translation termination codons via a stop codon readthrough mechanism. [provided by RefSeq, Oct 2015]
UniProt Comments for MPZ
myelin P0: a structural protein in peripheral nervous system Schwann cells. Forms an extracellular membrane face which guides the wrapping process and ultimately compacts adjacent lamellae. Defects cause of Charcot-Marie-Tooth disease, Dejerine-Sottas syndrome, congenital hypomyelination neuropathy, and Roussy-Levy syndrome.
Protein type: Membrane protein, integral; Adaptor/scaffold
Chromosomal Location of Human Ortholog: 1q23.3
Biological Process: synaptic transmission
Disease: Charcot-marie-tooth Disease, Axonal, Type 2i; Charcot-marie-tooth Disease, Axonal, Type 2j; Charcot-marie-tooth Disease, Demyelinating, Type 1b; Charcot-marie-tooth Disease, Dominant Intermediate D; Hypertrophic Neuropathy Of Dejerine-sottas; Neuropathy, Congenital Hypomyelinating Or Amyelinating, Autosomal Recessive; Roussy-levy Hereditary Areflexic Dystasia
Research Articles on MPZ
1. The obtained results depict that the protein with I30T mutation had variable structural conformation and dynamic behavior than native and mutant I30M of MPZ protein.
Precautions
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Disclaimer
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