Carbonic Anhydrase XIII / CA13, Recombinant Protein

CAXIII, FLJ37995, MGC59868

For Research Use Only. Not for use in diagnostic procedures.

E Coli

> 96 % as determined by SDS-PAGE

Lyophilized from sterile 20mM Tris, 0.5M NaCl, pH 8.0

Samples are stable for up to twelve months from date of receipt at -70 degree C

Manufactured in an ISO 9001:2015 Certified Laboratory.

Small volumes of CA13 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Background: The carbonic anhydrases (or carbonate dehydratases) are classified as metalloenzyme for its zinc ion prosthetic group and form a family of enzymes that catalyze the rapid interconversion of carbon dioxide and water to bicarbonate and protons, a reversible reaction that takes part in maintaining acid-base balance in blood and other tissues. The carbonic anhydrasekl (CA) family consists of at least 11 enzymatically active members and a few inactive homologous proteins. The CAXIII is a member of the CA family, which owns a globular molecule with high structural similarity to cytosolic isozymes, CAI, II, and III. Recombinant mouse CAXIII showed catalytic activity similar to those of mitochondrial CAV and cytosolic CAI. In human tissues, CAXIII expression was identified in the thymus, small intestine, spleen, prostate, ovary, colon, and testis. In mouse, positive tissues included the spleen, lung, kidney, heart, brain, skeletal muscle, and testis. In conclusion, the predicted amino acid sequence, structural model, distribution, and activity data suggest that CAXIII represents a novel enzyme, which may play important physiological roles in several organs.

Description: A DNA sequence encoding the human CA13 (NP_940986.1) (Met 1-His 262) was expressed, with a polyhistide tag at the C-terminus.

The recombinant human CA13 consisting of 268 amino acids and has a calculated molecular mass of 30.3 kDa. It migrates as an approximately 32 kDa band in SDS-PAGE under reducing conditions.

29,443 Da

carbonic anhydrase 13

carbonic anhydrase 13

Carbonic anhydrase 13

CA-XIII  [Similar Products]

Carbonic anhydrases (CAs) are a family of zinc metalloenzymes. For background information on the CA family, see MIM 114800.[supplied by OMIM, Mar 2008]

CA13: Reversible hydration of carbon dioxide. Belongs to the alpha-carbonic anhydrase family.

Protein type: EC 4.2.1.1; Energy Metabolism - nitrogen; Lyase

Chromosomal Location of Human Ortholog: 8q21.2

Cellular Component: cytosol

Molecular Function: carbonate dehydratase activity

Biological Process: bicarbonate transport

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