SDHAF2, Polyclonal Antibody

Succinate dehydrogenase complex assembly factor 2, SDH assembly factor 2, hSDH5, PGL2, SDH5

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

SDHAF2 antibody is predicted to not cross-react with other SDHAF protein family members.

Affinity chromatography purified via peptide column

Supplied in PBS containing 0.02% sodium azide.

Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Small volumes of anti-SDHAF2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

SDHAF2 (Succinate dehydrogenase complex assembly factor 2) encodes a mitochondrial protein needed for FAD cofactor attach to the SDH enzyme which plays a critical role in mitochondria. SDHAF2 is a tumor suppressor, but recent evidence suggests that somatic mutations of the SDHAF2 are unlikely to contribute to parathyroid tumor development in sporadic primary hyperparathyroidism.

Total protein Ab

ELISA (EIA), Western Blot (WB)

Western blot analysis of SDHAF2 in rat liver tissue lysate with SDHAF2 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.

19,599 Da

succinate dehydrogenase complex assembly factor 2

succinate dehydrogenase assembly factor 2, mitochondrial

Succinate dehydrogenase assembly factor 2, mitochondrial

SDH assembly factor 2; SDHAF2  [Similar Products]

SDHF2_HUMAN

This gene encodes a mitochondrial protein needed for the flavination of a succinate dehydrogenase complex subunit required for activity of the complex. Mutations in this gene are associated with paraganglioma.[provided by RefSeq, Jul 2010]

SDH5: a subunit of succinate dehydrogenase (SDH) complex II of the mitochondrial electron transport chain. SDH5 is required for insertion of FAD cofactor into SDHA, the catalytic subunit of succinate dehydrogenase (SDH) complex II. SDH is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Mutated in some cancers. Germline mutations cause hereditary paragangliomas type 2, or non-chromaffin paragangliomas type 2. Paragangliomas are rare tumors that arise from components of the neuroendocrine system.

Chromosomal Location of Human Ortholog: 11q12.2

Cellular Component: mitochondrion; mitochondrial matrix

Molecular Function: protein binding

Biological Process: mitochondrial electron transport, succinate to ubiquinone; protein-FAD linkage; protein amino acid dephosphorylation

Disease: Paragangliomas 2

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