AGXT, Polyclonal Antibody

Agxt; alanine-glyoxylate aminotransferase; Spat; Alanine-glyoxylate aminotransferase (Serine-pyruvate aminotransferase); Serine-pyruvate aminotransferase; angiotensin receptor 2; serine pyruvate aminotransferase precursor (AA -22 to 392); serine: pyruvate; Agxt antibody; alanine-glyoxylate aminotransferase antibody; Spat antibody; Alanine-glyoxylate aminotransferase (Serine-pyruvate aminotransferase) antibody; Serine-pyruvate aminotransferase antibody; angiotensin receptor 2 antibody; serine pyruvate aminotransferase precursor (AA -22 to 392) antibody; serine: pyruvate aminotransferase SPT antibody; serine: pyruvate/alanine: glyoxylate aminotransferase antibody; AGXT (rat)

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Goat

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul (lot specific)

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Manufactured in an ISO 9001:2008 Certified Laboratory.

Small volumes of anti-Agxt antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Peptide ELISA (EIA)

Peptide ELISA: Antibody detection limit dilution 1: 8000.
Western Blot: Preliminary experiments gave an approx.22kDa band in Mouse and Rat Liver lysates after 0.1ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 43.4kDa according to Rat NP_085914.1. The 22kDa band was successfully blocked by incubation with the immunizing peptide.

43,399 Da

alanine-glyoxylate aminotransferase

serine--pyruvate aminotransferase; serine--pyruvate aminotransferase, mitochondrial; serine--pyruvate aminotransferase, peroxisomal

Serine--pyruvate aminotransferase, mitochondrial

Agt1; SPT; AGT  [Similar Products]

SPYA_RAT

This gene encodes alanine-glyoxylate aminotransferase, which catalyzes the interconversion of L-alanine and glyoxylate to pyruvate and glycine. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. The longer transcript variant includes an upstream translation start codon and a downstream translation start codon. The upstream start codon initiates the translation of the mitochondrial enzyme precursor while the downstream start codon initiates the translation of the peroxisomal enzyme (see PMID:2332438). [provided by RefSeq, Feb 2013]

AGXT: Defects in AGXT are the cause of hyperoxaluria primary type 1 (HP1); also known as primary hyperoxaluria type I (PH1) and oxalosis I. HP1 is a rare autosomal recessive inborn error of glyoxylate metabolism characterized by increased excretion of oxalate and glycolate, and the progressive accumulation of insoluble calcium oxalate in the kidney and urinary tract. Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

Protein type: Mitochondrial; Transferase; Amino Acid Metabolism - alanine, aspartate and glutamate; Amino Acid Metabolism - glycine, serine and threonine; Motility/polarity/chemotaxis; EC 2.6.1.51; EC 2.6.1.44

Cellular Component: mitochondrial matrix; mitochondrion; peroxisomal matrix; peroxisome

Molecular Function: alanine-glyoxylate transaminase activity; amino acid binding; catalytic activity; protein homodimerization activity; protein self-association; pyridoxal phosphate binding; receptor binding; serine-pyruvate transaminase activity; transaminase activity

Biological Process: glycine biosynthetic process, by transamination of glyoxylate; glyoxylate catabolic process; glyoxylate metabolic process; L-alanine catabolic process; L-cysteine catabolic process; Notch signaling pathway; oxalic acid secretion; proteasomal protein catabolic process; pyruvate biosynthetic process; response to cAMP; response to glucocorticoid stimulus

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