Full Product Name
IL23R Polyclonal Antibody
Product Synonym Names
Interleukin-23 receptor; IL-23 receptor; IL-23R; IL23R
Product Gene Name
anti-IL23R antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q5VWK5
Species Reactivity
Human, Mouse
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Preparation and Storage
Store at-20 degree C for 1 year.
Other Notes
Small volumes of anti-IL23R antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-IL23R antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-IL23R antibody
WB: 1:500-2000
ELISA: 1:5000-20000
NCBI/Uniprot data below describe general gene information for IL23R. It may not necessarily be applicable to this product.
NCBI Accession #
NP_653302.2
[Other Products]
NCBI GenBank Nucleotide #
NM_144701.2
[Other Products]
UniProt Primary Accession #
Q5VWK5
[Other Products]
UniProt Secondary Accession #
Q4VGP1; Q4VGP2; Q4VGP3; Q4VGP4; Q4VGP5; Q4VGP6; Q5VWK7; Q8IW84; Q8NFQ9; Q96AS1; C9JGX4[Other Products]
UniProt Related Accession #
Q5VWK5[Other Products]
NCBI Official Full Name
interleukin-23 receptor
NCBI Official Synonym Full Names
interleukin 23 receptor
NCBI Official Symbol
IL23R [Similar Products]
NCBI Protein Information
interleukin-23 receptor
UniProt Protein Name
Interleukin-23 receptor
Protein Family
Interleukin-23 receptor
UniProt Gene Name
IL23R [Similar Products]
UniProt Synonym Gene Names
IL-23 receptor; IL-23R [Similar Products]
NCBI Summary for IL23R
The protein encoded by this gene is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner. [provided by RefSeq, Jul 2008]
UniProt Comments for IL23R
Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.
Research Articles on IL23R
1. Findings indicate that IL17A -197 G/A and IL23R H3Q are not associated with susceptibility to MM. However, IL-17 and IL-23R polymorphisms may affect severity, bone lesions, and extra-medullary disease in patients with MM.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
