HCRTR2, Polyclonal Antibody

OX2R

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

Antigen affinity purification

1.6mg/mL (lot specific)

Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

Manufactured in an ISO 9001:2015 Certified Laboratory.

Small volumes of anti-HCRTR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein binds the hypothalamic neuropeptides orexin A and orexin B. A related gene (HCRTR1) encodes a G-protein coupled receptor that selectively binds orexin A.

Stem cells

ELISA (EIA), Immunohistochemistry (IHC)

IHC: 1:50-1:200

Immunohistochemistry of paraffin-embedded Human lung cancer tissue using HCRTR2 Polyclonal Antibody at dilution 1:50

Immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using HCRTR2 Polyclonal Antibody at dilution 1:50

50,694 Da

hypocretin (orexin) receptor 2

orexin receptor type 2; hypocretin receptor type 2; orexin type-2 receptor; ox-2-R; ox2-R

Orexin receptor type 2

Ox-2-R; Ox2-R; Ox2R  [Similar Products]

OX2R_HUMAN

The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein binds the hypothalamic neuropeptides orexin A and orexin B. A related gene (HCRTR1) encodes a G-protein coupled receptor that selectively binds orexin A. [provided by RefSeq, Jan 2009]

HCRTR2: Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 1

Chromosomal Location of Human Ortholog: 6p12

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: neuropeptide receptor activity; orexin receptor activity; peptide hormone binding; peptide binding

Biological Process: synaptic transmission; neuropeptide signaling pathway; circadian sleep/wake cycle process; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); feeding behavior; cellular response to hormone stimulus; regulation of circadian sleep/wake cycle, sleep

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