GDF1, Polyclonal Antibody

DORV; DTGA3; Embryonic growth/differentiation factor 1; GDF 1; GDF-1; GDF1; GDF1_HUMAN; Growth differentiation factor 1

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

GDF1 antibody detects endogenous levels of total GDF1

The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.

Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

1mg/ml (lot specific)

Store at -20 degree C. Stable for 12 months from date of receipt.

Manufactured in an ISO 9001:2015 Certified Laboratory.

Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.

Small volumes of anti-GDF1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Function: May mediate cell differentiation events during embryonic development.
Subunit Structure: Homodimer; disulfide-linked.
Similarity: Belongs to the TGF-beta family.

Western Blot (WB), ELISA (EIA)

WB: 1:1000-3000

Western blot analysis GDF1 using K562 whole cell lysates

Observed: 39 kDa
Predicted: 40 kDa

growth differentiation factor 1

embryonic growth/differentiation factor 1

Embryonic growth/differentiation factor 1

GDF-1  [Similar Products]

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. Studies in rodents suggest that this protein is involved in the establishment of left-right asymmetry in early embryogenesis and in neural development in later embryogenesis. The encoded protein is translated from a bicistronic mRNA that also encodes ceramide synthase 1. Mutations in this gene are associated with several congenital cardiovascular malformations. [provided by RefSeq, Jul 2016]

May mediate cell differentiation events during embryonic development.

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