Product Name
Filamin (FLNB), Monoclonal Antibody
Full Product Name
Anti-Filamin Antibody (clone FLMN01)
Product Synonym Names
Mouse Monoclonal (IgG1) to Human Filamin
Product Gene Name
anti-FLNB antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human
Predicted: Chicken, Rabbit, Mouse, Guinea pig, Rat
Purity/Purification
Protein G purified
Form/Format
10mM PBS, pH 7.4, with 0.2% BSA and 0.09% Sodium Azide
Immunogen
Platelet filamin.
Preparation and Storage
Store at 4 degree C, avoid freezing.
Other Notes
Small volumes of anti-FLNB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-FLNB antibody
ELISA (EIA), Immunohistochemistry (IHC) Paraffin, Western Blot (WB)
Application Notes for anti-FLNB antibody
IHC-P: 10 ug/ml
WB: 1-2 ug/ml
Immunohistochemistry (IHC) of anti-FLNB antibody
Anti-Filamin antibody IHC of human prostate, smooth muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 10 ug/ml.
NCBI/Uniprot data below describe general gene information for FLNB. It may not necessarily be applicable to this product.
NCBI Accession #
AAF72339.1
[Other Products]
UniProt Secondary Accession #
Q13706; Q59EC2; Q60FE7; Q6MZJ1; Q8WXS9; Q8WXT0; B2ZZ83; B2ZZ84; B2ZZ85; C9JKE6; C9JMC4[Other Products]
UniProt Related Accession #
O75369[Other Products]
Molecular Weight
276,939 Da[Similar Products]
NCBI Official Full Name
filamin
NCBI Official Synonym Full Names
filamin B
NCBI Official Symbol
FLNB [Similar Products]
NCBI Official Synonym Symbols
AOI; FH1; SCT; TAP; LRS1; TABP; FLN-B; FLN1L; ABP-278; ABP-280
[Similar Products]
NCBI Protein Information
filamin-B
UniProt Protein Name
Filamin-B
UniProt Synonym Protein Names
ABP-278; ABP-280 homolog; Actin-binding-like protein; Beta-filamin; Filamin homolog 1; Fh1; Filamin-3; Thyroid autoantigen; Truncated actin-binding protein; Truncated ABP
UniProt Gene Name
FLNB [Similar Products]
UniProt Synonym Gene Names
FLN1L; FLN3; TABP; TAP; FLN-B; Fh1; Truncated ABP [Similar Products]
NCBI Summary for FLNB
This gene encodes a member of the filamin family. The encoded protein interacts with glycoprotein Ib alpha as part of the process to repair vascular injuries. The platelet glycoprotein Ib complex includes glycoprotein Ib alpha, and it binds the actin cytoskeleton. Mutations in this gene have been found in several conditions: atelosteogenesis type 1 and type 3; boomerang dysplasia; autosomal dominant Larsen syndrome; and spondylocarpotarsal synostosis syndrome. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Nov 2009]
UniProt Comments for FLNB
Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro.
Research Articles on FLNB
1. G, encoding p.(Tyr233Cys) mutation was detected in buccal mucosa and fibroblast DNA.">We report the case of a male patient with Larsen syndrome found to be mosaic for a novel point mutation in FLNB in whom it was possible to provide evidence-based personalized counseling on transmission risk to future offspring. Using dideoxy sequencing, a low-level FLNB c.698A>G, encoding p.(Tyr233Cys) mutation was detected in buccal mucosa and fibroblast DNA.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
