Product Name
Filamin B (FLNB), Polyclonal Antibody
Full Product Name
Anti-Filamin B Antibody
Product Synonym Names
FLN1L; FLN3; TABP; TAP; Filamin-B; FLN-B; ABP-278; ABP-280 homolog; Actin-binding-like protein; Beta-filamin; Filamin homolog 1; Fh1; Filamin-3; Thyroid autoantigen; Truncated actin-binding protein; Truncated ABP
Product Gene Name
anti-FLNB antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O75369
Species Reactivity
Human, Mouse, Rat
Specificity
Recognizes endogenous levels of Filamin B protein.
Purity/Purification
Purified by immunogen affinity chromatography
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Immunogen
Recombinant full length protein of human Filamin B
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-FLNB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-FLNB antibody
Rabbit polyclonal antibody to Filamin B
Applications Tested/Suitable for anti-FLNB antibody
Western Blot (WB)
Application Notes for anti-FLNB antibody
WB: 1/500 - 1/2000
Western Blot (WB) of anti-FLNB antibody
Western blot analysis of Filamin B expression in Hela (A) whole cell lysates.
NCBI/Uniprot data below describe general gene information for FLNB. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001157789.1
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NCBI GenBank Nucleotide #
NM_001164317.1
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UniProt Primary Accession #
O75369
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UniProt Secondary Accession #
Q13706; Q59EC2; Q60FE7; Q6MZJ1; Q8WXS9; Q8WXT0; B2ZZ83; B2ZZ84; B2ZZ85; C9JKE6; C9JMC4[Other Products]
UniProt Related Accession #
O75369[Other Products]
Molecular Weight
276,939 Da
NCBI Official Full Name
filamin-B isoform 1
NCBI Official Synonym Full Names
filamin B
NCBI Official Symbol
FLNB [Similar Products]
NCBI Official Synonym Symbols
AOI; FH1; SCT; TAP; LRS1; TABP; FLN-B; FLN1L; ABP-278; ABP-280
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NCBI Protein Information
filamin-B
UniProt Protein Name
Filamin-B
UniProt Synonym Protein Names
ABP-278; ABP-280 homolog; Actin-binding-like protein; Beta-filamin; Filamin homolog 1; Fh1; Filamin-3; Thyroid autoantigen; Truncated actin-binding protein; Truncated ABP
UniProt Gene Name
FLNB [Similar Products]
UniProt Synonym Gene Names
FLN1L; FLN3; TABP; TAP; FLN-B; Fh1; Truncated ABP [Similar Products]
NCBI Summary for FLNB
This gene encodes a member of the filamin family. The encoded protein interacts with glycoprotein Ib alpha as part of the process to repair vascular injuries. The platelet glycoprotein Ib complex includes glycoprotein Ib alpha, and it binds the actin cytoskeleton. Mutations in this gene have been found in several conditions: atelosteogenesis type 1 and type 3; boomerang dysplasia; autosomal dominant Larsen syndrome; and spondylocarpotarsal synostosis syndrome. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Nov 2009]
UniProt Comments for FLNB
Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro.
Research Articles on FLNB
1. This is the first identified mutation in the dimerization domain of FLNB. This loss-of-function frameshift mutation in FLNB causes autosomal-recessive SCT with rarely reported rib anomalies. This report demonstrates the involvement of rib anomaly in SCT and its causative mutation in the dimerization domain of FLNB.
Precautions
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Disclaimer
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