Product Name
TGF beta II receptor (27-85) (TGFBR2), Polyclonal Antibody
Full Product Name
TGF beta II receptor (27-85)
Product Synonym Names
TGBb Type II r; TGF beta II receptor; transforming growth factor receptor beta; Type II
Product Gene Name
anti-TGFBR2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 2; NC_006089.3 (40385525..40447632). Location: chromosome: 2
3D Structure
ModBase 3D Structure for Q90999
Species Reactivity
Chicken
Purity/Purification
Ammonium Sulfate Precipitation
Form/Format
Provided as solution in phosphate buffered saline with 0.08% sodium azide
Immunogen
A GST fusion protein containing chick transforming growth factor type II receptor a.a.27-85
Positive Control
Recombinant proteins conjugated to OVA, GST, His tags and other. Native TGF beta II proteins.
Preparation and Storage
Product should be stored at -20 degree C. Aliquot to avoid freeze/thaw cycles
Other Notes
Small volumes of anti-TGFBR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-TGFBR2 antibody
The immunogen used was a recombinant protein containing chick transforming growth factor type II receptor region a.a.27-85. Epithelial-mesenchymal transformation is a critical event in the development of many organ systems including heart. Transforming Growth Factor (TGF) is one of a number of factors that mediates this transformation. Antibodies directed against TGF Type II receptor block both the endicardial cell activation and subsequent migration that constitute transformation in the chick atrioventricular (AV) cushion.
Product Categories/Family for anti-TGFBR2 antibody
Polyclonal Antibody; Cytokines
Applications Tested/Suitable for anti-TGFBR2 antibody
Immunohistochemistry (IHC)
NCBI/Uniprot data below describe general gene information for TGFBR2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_990759.1
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NCBI GenBank Nucleotide #
NM_205428.1
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UniProt Primary Accession #
Q90999
[Other Products]
UniProt Related Accession #
Q90999[Other Products]
Molecular Weight
63 kDa[Similar Products]
NCBI Official Full Name
TGF-beta receptor type-2
NCBI Official Synonym Full Names
transforming growth factor, beta receptor II (70/80kDa)
NCBI Official Symbol
TGFBR2 [Similar Products]
NCBI Protein Information
TGF-beta receptor type-2; TGFR-2; tbetaR-II; TGF-beta receptor type II; TGF-beta type II receptor; transforming growth factor-beta receptor type II; transforming growth factor-beta type II receptor
UniProt Protein Name
TGF-beta receptor type-2
UniProt Synonym Protein Names
TGF-beta type II receptor; Transforming growth factor-beta receptor type II
Protein Family
TGF-beta receptor
UniProt Gene Name
TGFBR2 [Similar Products]
UniProt Synonym Gene Names
TGFR-2; TGF-beta receptor type II; TbetaR-II [Similar Products]
UniProt Entry Name
TGFR2_CHICK
UniProt Comments for TGFBR2
Function: Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways
By similarity. Ref.1
Catalytic activity: ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
Cofactor: Magnesium or manganese
By similarity.
Subunit structure: Heterohexamer; TGFB1, TGFB2 and TGFB3 homodimeric ligands assemble a functional receptor composed of two TGFBR1 and TGFBR2 heterodimers to form a ligand-receptor heterohexamer
By similarity.
Subcellular location: Cell membrane; Single-pass type I membrane protein
By similarity.
Tissue specificity: Detected at low levels in embryonic heart, brain and lung. Detected at high levels in hatchling heart and lung. Ref.1
Post-translational modification: Phosphorylated on a Ser/Thr residue in the cytoplasmic domain
By similarity.
Sequence similarities: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.Contains 1 protein kinase domain.
Research Articles on TGFBR2
1. Data show that TGF-beta1, -beta2, and -beta3 and their receptors have distinct spatiotemporal developmental protein localization patterns in the developing tendon and suggest that these isoforms have independent roles in tendon development.
Precautions
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Disclaimer
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