Full Product Name
ABI1 (Phospho-Tyr212) Antibody
Product Gene Name
anti-ABI1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q8IZP0
Species Reactivity
Human, Mouse, Rat
Concentration
1.0mg/ml (lot specific)
Other Notes
Small volumes of anti-ABI1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-ABI1 antibody
Western Blot (WB)
NCBI/Uniprot data below describe general gene information for ABI1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001012768.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001012750.2
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UniProt Primary Accession #
Q8IZP0
[Other Products]
UniProt Secondary Accession #
O15147; O76049; O95060; Q5T2R3; Q5T2R4; Q5T2R6; Q5T2R7; A9Z1Y6; B3KX62; B4DQ58; H7BXI6[Other Products]
UniProt Related Accession #
Q8IZP0[Other Products]
Molecular Weight
53,912 Da
NCBI Official Full Name
abl interactor 1 isoform b
NCBI Official Synonym Full Names
abl interactor 1
NCBI Official Symbol
ABI1 [Similar Products]
NCBI Official Synonym Symbols
E3B1; ABI-1; ABLBP4; NAP1BP; SSH3BP; SSH3BP1
[Similar Products]
NCBI Protein Information
abl interactor 1
UniProt Protein Name
Abl interactor 1
UniProt Synonym Protein Names
Abelson interactor 1; Abi-1; Abl-binding protein 4; AblBP4; Eps8 SH3 domain-binding protein; Eps8-binding protein; Nap1-binding protein; Nap1BP; Spectrin SH3 domain-binding protein 1; e3B1
Protein Family
Abl interactor
UniProt Gene Name
ABI1 [Similar Products]
UniProt Synonym Gene Names
SSH3BP1; Abi-1; AblBP4; Eps8-binding protein; Nap1BP [Similar Products]
NCBI Summary for ABI1
This gene encodes a member of the Abelson-interactor family of adaptor proteins. These proteins facilitate signal transduction as components of several multiprotein complexes, and regulate actin polymerization and cytoskeletal remodeling through interactions with Abelson tyrosine kinases. The encoded protein plays a role in macropinocytosis as a component of the WAVE2 complex, and also forms a complex with EPS8 and SOS1 that mediates signal transduction from Ras to Rac. This gene may play a role in the progression of several malignancies including melanoma, colon cancer and breast cancer, and a t(10;11) chromosomal translocation involving this gene and the MLL gene has been associated with acute myeloid leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 14. [provided by RefSeq, Sep 2011]
UniProt Comments for ABI1
May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons.
Research Articles on ABI1
1. Suggest that Abi1 acts as a tumor-promoting gene in epithelial ovarian cancer progression, which may lead to unfavorable prognosis.
Precautions
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Disclaimer
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