Hedgehog Homolog, Indian (IHH), Recombinant Protein

BDA1; HHG2

For Research Use Only. Not for use in diagnostic procedures.

E Coli

> 90%

Freeze-dried powder

Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.

Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.

Small volumes of IHH recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Recombinant Protein

Positive Control, Immunogen, SDS-PAGE, Western Blot (WB)

20.9kDa

indian hedgehog

indian hedgehog protein

Indian hedgehog protein

IHH  [Similar Products]

This gene encodes a member of the hedgehog family of proteins. The encoded preproprotein is proteolytically processed to generate multiple protein products, including an N-terminal fragment that is involved in signaling. Hedgehog family proteins are essential secreted signaling molecules that regulate a variety of developmental processes including growth, patterning and morphogenesis. The protein encoded by this gene specifically plays a role in bone growth and differentiation. Mutations in this gene are the cause of brachydactyly type A1, which is characterized by shortening or malformation of the fingers and toes. Mutations in this gene are also the cause of acrocapitofemoral dysplasia. [provided by RefSeq, Nov 2015]

IHH: Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP). Expressed in embryonic lung, and in ***** kidney and liver. Belongs to the hedgehog family.

Chromosomal Location of Human Ortholog: 2q35

Cellular Component: plasma membrane

Molecular Function: calcium ion binding; patched binding

Biological Process: heart looping; negative regulation of alpha-beta T cell differentiation; negative regulation of immature T cell proliferation in the thymus; negative regulation of T cell differentiation in the thymus; positive regulation of alpha-beta T cell differentiation; positive regulation of smoothened signaling pathway; positive regulation of T cell differentiation in the thymus; skeletal development; smoothened signaling pathway

Disease: Acrocapitofemoral Dysplasia; Brachydactyly, Type A1

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