LEPR, Polyclonal Antibody

Leptin receptor; LEP-R; HuB219; OB receptor; OB-R; CD295; LEPR; DB; OBR

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit Ig

Rabbit

This LEPR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 957-986 amino acids from the C-terminal region of human LEPR.

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Vial Concentration: 0.5 (lot specific)

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Small volumes of anti-LEPR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

The protein encoded by this gene belongs to the gp130
family of cytokine receptors that are known to stimulate gene
transcription via activation of cytosolic STAT proteins. This
protein is a receptor for leptin (an adipocyte-specific hormone
that regulates body weight), and is involved in the regulation of
fat metabolism, as well as in a novel hematopoietic pathway that is
required for normal lymphopoiesis. Mutations in this gene have been
associated with obesity and pituitary dysfunction. Alternatively
spliced transcript variants encoding different isoforms have been
described for this gene. It is noteworthy that this gene and LEPROT
gene (GeneID:54741) share the same promoter and the first 2 exons,
however, encode distinct proteins (PMID:9207021).

Cancer; Cardiovascular; Metabolism; Neuroscience; Signal Transduction

Western Blot (WB), ELISA (EIA)

WB~~1:1000

LEPR Antibody (C-term) western blot analysis in mouse brain tissue lysates (35ug/lane).This demonstrates the LEPR antibody detected the LEPR protein (arrow).

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leptin receptor

leptin receptor

Leptin receptor

DB; OBR; LEP-R; OB-R  [Similar Products]

LEPR_HUMAN

The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021).[provided by RefSeq, Nov 2010]

LEPR: the receptor for leptin (obesity factor). A single-transmembrane-domain receptor of the cytokine receptor family. On ligand binding, mediates signaling through JAK2/STAT3. Involved in the regulation of fat metabolism and, in a hematopoietic pathway, required for normal lymphopoiesis. May play a role in reproduction. Five alternatively spliced transcript variants have been reported.

Protein type: Membrane protein, integral; Receptor, cytokine

Chromosomal Location of Human Ortholog: 1p31

Cellular Component: plasma membrane; extracellular region; integral to membrane; receptor complex

Molecular Function: identical protein binding; hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding; transmembrane receptor activity

Biological Process: cholesterol metabolic process; cell surface receptor linked signal transduction; cytokine and chemokine mediated signaling pathway; negative regulation of hydrolase activity; multicellular organismal development; negative regulation of gluconeogenesis; energy reserve metabolic process

Disease: Leptin Receptor Deficiency

Hu, M., et al. Pharmacogenet. Genomics 20(10):634-637(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
de Luis, D.A., et al. Ann. Nutr. Metab. 57(2):89-94(2010)
Louis, G.W., et al. J. Neurosci. 30(34):11278-11287(2010)
Sarzynski, M.A., et al. Int J Obes (Lond) (2010) In press :

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