Full Product Name
MNX1, ID (MNX1, HLXB9, Motor neuron and pancreas homeobox protein 1, Homeobox protein HB9)
Product Synonym Names
Anti -MNX1, ID (MNX1, HLXB9, Motor neuron and pancreas homeobox protein 1, Homeobox protein HB9)
Product Gene Name
anti-MNX1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 7; NC_000007.13 (156797547..156803347, complement). Location: 7q36
3D Structure
ModBase 3D Structure for P50219
Species Reactivity
Human, Mouse
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Immunogen
MNX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 241-271 amino acids from the Central region of human MNX1.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-MNX1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-MNX1 antibody
This gene encodes a nuclear protein, which contains a homeobox domain and is a transcription factor. Mutations in this gene result in Currarino syndrome, an autosomic dominant congenital malformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Product Categories/Family for anti-MNX1 antibody
Antibodies; Abs to Transcription Factors, Zinc, Ring, Homeobox
Applications Tested/Suitable for anti-MNX1 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-MNX1 antibody
Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
NCBI/Uniprot data below describe general gene information for MNX1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001158727.1
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NCBI GenBank Nucleotide #
NM_001165255.1
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UniProt Primary Accession #
P50219
[Other Products]
UniProt Secondary Accession #
Q9Y648; F5H401[Other Products]
UniProt Related Accession #
P50219[Other Products]
Molecular Weight
40,569 Da[Similar Products]
NCBI Official Full Name
motor neuron and pancreas homeobox protein 1 isoform 2
NCBI Official Synonym Full Names
motor neuron and pancreas homeobox 1
NCBI Official Symbol
MNX1 [Similar Products]
NCBI Official Synonym Symbols
HB9; HLXB9; SCRA1; HOXHB9
[Similar Products]
NCBI Protein Information
motor neuron and pancreas homeobox protein 1; homeobox HB9; homeobox protein HB9
UniProt Protein Name
Motor neuron and pancreas homeobox protein 1
UniProt Synonym Protein Names
Homeobox protein HB9
Protein Family
Motor neuron and pancreas homeobox protein
UniProt Gene Name
MNX1 [Similar Products]
UniProt Synonym Gene Names
HLXB9 [Similar Products]
UniProt Entry Name
MNX1_HUMAN
NCBI Summary for MNX1
This gene encodes a nuclear protein, which contains a homeobox domain and is a transcription factor. Mutations in this gene result in Currarino syndrome, an autosomic dominant congenital malformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
UniProt Comments for MNX1
MNX1: Putative transcription factor involved in pancreas development and function. Defects in MNX1 are a cause of Currarino syndrome (CURRAS). The triad of a presacral tumor, sacral agenesis and anorectal malformation constitutes the Currarino syndrome which is caused by dorsal-ventral patterning defects during embryonic development. The syndrome occurs in the majority of patients as an autosomal dominant trait.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 7q36
Cellular Component: nucleus
Molecular Function: sequence-specific DNA binding; transcription factor activity
Biological Process: regulation of transcription from RNA polymerase II promoter; anatomical structure morphogenesis; transcription, DNA-dependent; spinal cord motor neuron cell fate specification; neuron migration; nerve development; motor axon guidance; endocrine pancreas development; dorsoventral neural tube patterning; humoral immune response; post-embryonic development
Disease: Currarino Syndrome
Research Articles on MNX1
1. study describes a Norwegian family with typical Currarino syndrome in which a heterozygous deletion removes the entire MNX1 gene but no other known genes; also report MNX1 mutations in 3other Norwegian families and confirm that the GCC12 repeat (c.373_375[12]) is a normal allelic variant
Precautions
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Disclaimer
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