Full Product Name
AMER1 Polyclonal Antibody
Product Synonym Names
WTX; OSCS; FAM123B; RP11-403E24.2
Product Gene Name
anti-AMER1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen affinity purification
Concentration
2.1mg/mL (lot specific)
Immunogen
Synthetic peptide of human AMER1
Buffer
PBS with 0.05% sodium azide, 50% glycerol, pH7.3
Preparation and Storage
Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-AMER1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-AMER1 antibody
The protein encoded by this gene upregulates trancriptional activation by the Wilms tumor protein and interacts with many other proteins, including CTNNB1, APC, AXIN1, and AXIN2. Defects in this gene are a cause of osteopathia striata with cranial sclerosis (OSCS).
Product Categories/Family for anti-AMER1 antibody
Stem cells
Applications Tested/Suitable for anti-AMER1 antibody
ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-AMER1 antibody
IHC: 1:50-1:200
Immunohistochemistry (IHC) of anti-AMER1 antibody
Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using AMER1 Polyclonal Antibody at dilution 1:40
Immunohistochemistry (IHC) of anti-AMER1 antibody
Immunohistochemistry of paraffin-embedded Human gastric cancer tissue using AMER1 Polyclonal Antibody at dilution 1:40
NCBI/Uniprot data below describe general gene information for AMER1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_689637.3
[Other Products]
NCBI GenBank Nucleotide #
NM_152424.3
[Other Products]
UniProt Secondary Accession #
Q8N885; A2IB86[Other Products]
UniProt Related Accession #
Q5JTC6[Other Products]
Molecular Weight
87,823 Da
NCBI Official Full Name
APC membrane recruitment protein 1
NCBI Official Synonym Full Names
APC membrane recruitment protein 1
NCBI Official Symbol
AMER1 [Similar Products]
NCBI Official Synonym Symbols
WTX; OSCS; FAM123B
[Similar Products]
NCBI Protein Information
APC membrane recruitment protein 1; RP11-403E24.2; Wilms tumor gene on the X chromosome protein; Wilms tumor on the X; adenomatous polyposis coli membrane recruitment 1; family with sequence similarity 123B; protein FAM123B
UniProt Protein Name
APC membrane recruitment protein 1
UniProt Synonym Protein Names
Protein FAM123B; Wilms tumor gene on the X chromosome protein
Protein Family
APC membrane recruitment protein
UniProt Gene Name
AMER1 [Similar Products]
UniProt Synonym Gene Names
FAM123B; WTX; Amer1 [Similar Products]
UniProt Entry Name
AMER1_HUMAN
NCBI Summary for AMER1
The protein encoded by this gene upregulates trancriptional activation by the Wilms tumor protein and interacts with many other proteins, including CTNNB1, APC, AXIN1, and AXIN2. Defects in this gene are a cause of osteopathia striata with cranial sclerosis (OSCS). [provided by RefSeq, May 2010]
UniProt Comments for AMER1
WTX: a peripheral membrane protein on the cytoplasmic side that shuttles between nucleus and cytoplasm. Detected in nuclear paraspeckles that are found close to splicing speckles. Enhances trancription activation by WT1. Promotes CTNNB1 ubiquitination and degradation. Antagonizes Wnt and CTNNB1 signaling. Inactivated in approximately one-third of Wilms tumors. Detected in fetal and ***** kidney, brain and spleen. Involved in kidney development. Interacts with CTNNB1, AXIN1, KEAP1, APC and BTRC. Interacts with SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes containing BTRC and/or FBXW11. Identified in a complex containing CTNNB1, APC, AXIN1 and AXIN2. Two alternatively spliced human isoforms have been reported.
Chromosomal Location of Human Ortholog: Xq11.2
Cellular Component: plasma membrane; nucleus; cytosol
Molecular Function: protein binding; phosphatidylinositol-4,5-bisphosphate binding; beta-catenin binding
Biological Process: Wnt receptor signaling pathway
Disease: Osteopathia Striata With Cranial Sclerosis
Research Articles on AMER1
1. T, p.Glu349*) in the WTX gene.">A nonsense mutation (c.1045C>T, p.Glu349*) in the WTX gene.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
