CNTNAP2, Polyclonal Antibody

Contactin-associated protein-like 2; Cell recognition molecule Caspr2; CNTNAP2; CASPR2 {ECO:0000303|PubMed:10624965}; KIAA0868

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit Ig

Rabbit

This CNTNAP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1079-1106 amino acids from the Central region of human CNTNAP2.

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Vial Concentration: 0.5 (lot specific)

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Small volumes of anti-CNTNAP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

CNTNAP2 is a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C omain,discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains and a putative PDZ . This protein is localized at the juxtaparanodes of myelinated axons, and mediates interactions between neurons and glia during nervous system development and is also involved in localization of potassium channels within differentiating axons.

Neuroscience

Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC)

WB~~1:1000

Western blot analysis of CNTNAP2 Antibody (Center) in CEM cell line lysates (35ug/lane). CNTNAP2 (arrow) was detected using the purified Pab.

Formalin-fixed and paraffin-embedded mouse brain tissue reacted with CNTNAP2 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

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contactin associated protein-like 2

contactin-associated protein-like 2

Contactin-associated protein-like 2

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CNTP2_HUMAN

This gene encodes a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains and a putative PDZ . This protein is localized at the juxtaparanodes of myelinated axons, and mediates interactions between neurons and glia during nervous system development and is also involved in localization of potassium channels within differentiating axons. This gene encompasses almost 1.5% of chromosome 7 and is one of the largest genes in the human genome. It is directly bound and regulated by forkhead box protein P2 (FOXP2), a transcription factor related to speech and language development. This gene has been implicated in multiple neurodevelopmental disorders, including Gilles de la Tourette syndrome, schizophrenia, epilepsy, autism, ADHD and mental retardation.[provided by RefSeq, Mar 2010]

CNTNAP2: May play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the juxtaparanodal region of the axo-glial junction. Associates with KCNA2. Predominantly expressed in nervous system. Belongs to the neurexin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 7q35

Cellular Component: Golgi apparatus; voltage-gated potassium channel complex; cell surface; membrane; cell soma; axon; early endosome; dendrite; integral to membrane; perikaryon; axolemma

Molecular Function: enzyme binding

Biological Process: striatum development; limbic system development; neuron recognition; transmission of nerve impulse; learning; thalamus development; social behavior; ***** behavior; clustering of voltage-gated potassium channels; cerebral cortex development; brain development; cell adhesion; neurite development

Disease: Autism, Susceptibility To, 15; Cortical Dysplasia-focal Epilepsy Syndrome

Denisenko-Nehrbass,N., et.al., Eur. J. Neurosci. 17 (2), 411-416 (2003)
Nakayama,M., et.al., Genome Res. 12 (11), 1773-1784 (2002)

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