Full Product Name
F11 Antibody
Product Gene Name
anti-F11 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P03951
Other Notes
Small volumes of anti-F11 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Western Blot (WB) of anti-F11 antibody
Western blot analysis F11 using Jurkat whole cell lysates
NCBI/Uniprot data below describe general gene information for F11. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000119.1
[Other Products]
NCBI GenBank Nucleotide #
NM_000128.3
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UniProt Primary Accession #
P03951
[Other Products]
UniProt Secondary Accession #
Q4W5C2; Q9Y495; D3DP64[Other Products]
UniProt Related Accession #
P03951[Other Products]
Molecular Weight
63,840 Da
NCBI Official Full Name
coagulation factor XI isoform 1 preproprotein
NCBI Official Synonym Full Names
coagulation factor XI
NCBI Official Symbol
F11 [Similar Products]
NCBI Official Synonym Symbols
FXI; PTA
[Similar Products]
NCBI Protein Information
coagulation factor XI
UniProt Protein Name
Coagulation factor XI
UniProt Synonym Protein Names
Plasma thromboplastin antecedent; PTA
Protein Family
Coagulation factor
UniProt Gene Name
F11 [Similar Products]
UniProt Synonym Gene Names
FXI; PTA [Similar Products]
NCBI Summary for F11
This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality. [provided by RefSeq, Jul 2008]
UniProt Comments for F11
Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.
Research Articles on F11
1. In this
prospective cohort of elderly *****s, there was no statistically significant association of higher FXI levels with incident coronary heart disease and stroke.
Precautions
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Disclaimer
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